摘要
他汀类药物是目前临床上应用最多的调脂药。近年来不断有证据表明,他汀类药物不仅具有调脂作用,而且可以改善内皮细胞功能,减少动脉硬化斑块中的炎性成分,具有抗炎、抗动脉粥样硬化的作用。研究证实,他汀类调脂药在冠状动脉粥样硬化性心脏病一级预防、二级预防及心脏围术期具有广泛的心血管保护作用。另外,也有研究试图探索他汀类药物对于心房颤动、心力衰竭等其他心血管疾病是否也同样具有保护作用。同时,由于其在临床的广泛的、大剂量的应用,其安全性也日益受到重视。
Statins is currently the most commonly used lipid-lowering drug. Recently, accumulating evi- dence suggests that statins not only affects lipid metabolism but also alters endothelial function,and decreases the inflammatory component of plaques, thus has the effect of anti-inflammation and anti- atherosclerosis. Evi- dence suggests that statins has general cardioproteetive effects as primary, secondary prevention of coronary heart disease, and peri-corunary intervention of coronary atherosclerotic heart disease. Other researches explored whether it has the same effect on atrial fibrillation, heart failure. Besides, due to its wide and high- dose application, its adverse reaction has also been concerned.
出处
《医学综述》
2013年第11期2051-2054,共4页
Medical Recapitulate
