摘要
目的:研究五脏应时理论中的心应夏理论与褪黑素的关联性。方法:40只SD大鼠分为正常对照组、松果腺摘除手术组、伪手术组、心气虚组共4组,夏至当天酶联免疫法检测其血清褪黑素(MLT)、血浆心钠素(ANP)和心脏组织M胆碱受体的水平。结果:手术组大鼠血清MLT低于正常对照组和伪手术组(P<0.05);血浆ANP低于正常对照组(P<0.05)。心气虚组大鼠与正常对照组相比血清MLT水平下降(P<0.01);血浆ANP水平下降(P<0.05);心脏M受体表达水平下降(P<0.05)。结论:松果腺摘除手术组大鼠褪黑素下降可能影响其血浆心钠素水平,心钠素可能参与了褪黑素对心血管系统的调控过程;心气虚证大鼠血清褪黑素降低,应夏的能力下降。
Objective：This study was to explore the relationship between melatonin and the theory of heart corresponding to summer which belongs to the theory of Five-zang organs corresponding to the seasons.Methods：Forty Sprague-Dawley rats were randomly divided into the blank group,the pinealectomy group,the sham-operated group,the heart-Qi deficiency syndrome group.The levels of MLT in serum,ANP in plasma and M-AChR in heart were measured by using ELISA on the day of Xiazhi.Results：Compared with blank group and sham-operated group,the MLT level in serum was decreased in pinealectomy group;the ANP level in plasma of pinealectomy group was lower than that of blank group.The MLT level in serum,the ANP level in plasma and the M-AChR level in heart of heart-Qi deficiency syndrome group were lower than those of blank group.Conclusion：The decrease of plasma ANP in pinealectomy group may be related to the deficiency of MLT.ANP may be a sort of interdiary substance which participates in the regulating process that the MLT acts on the cardiovascular system.The heart-Qi deficiency syndrome rats′ability of corresponding to summer is decreased.
出处
《辽宁中医杂志》
CAS
2013年第7期1354-1356,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(81173381)
关键词
心应夏
褪黑素
心钠素
M受体
heart corresponding to summer
MLT
ANP
M-AChR
