摘要
认知功能障碍直接影响人们的生活,动物模型的研究为筛选具有改善认知功能的药物和防治认知损伤提供研究载体。综述近年来认知损伤动物模型的常见制备方法,包括化学物质损伤、物理损伤、转基因鼠模型、老化鼠模型等。化学物质如东莨菪碱造成的获得性记忆障碍模型已成为筛选改善认知损伤药物的公认模型,物理损伤模型为创伤性脑损伤的研究提供了重要的研究基础,其中缺血缺氧性脑损伤模型是预防和研究脑血管疾病导致的认知损伤的关键。
Cognitive dysfunction could directly impact the reflection of cerebral cortex and people’s advanced normal life, while animal models provide a reference for screening drugs that could improve the cognitive functions, including attention, memory, learning, thinking, language expression, spatial visual function, and so on. This paper reviews the frequently-used models induced by different mechanisms including chemical substances, physical damage, transgenic mouse, senescence-accelerated mouse, and so on. Acquired memory disorders model induced by chemical substances such as scopolamine has become the generally accepted model for screening drugs that could improve the cognitive functions. Physical damage model provides an important basis for the study of traumatic brain injury, especially hypoxia-ischemia brain damage model, which plays a key role in preventing the cognitive impairment caused by cerebrovascular diseases.
出处
《药物评价研究》
CAS
2013年第3期218-223,共6页
Drug Evaluation Research
基金
国家科技重大专项资助项目(2012ZX09J12110-01C)
关键词
认知损伤
记忆障碍
动物模型
胆碱能系统
cognitive impairment
memory barrier
animal model
cholinergic system
