摘要
目的：探讨在经外周静脉置入中心静脉导管（peripherally inserted central catheter,PICC）的肺癌患者中,用肝素钠（125U/ml）稀释液进行封管对其血栓前状态的影响。方法：随机抽取我科20例PICC肺癌患者,在置管后采用肝素钠稀释液进行封管,通过对PICC置管前0-1 d（T0期）、置管后2-3 d（T1期）与血栓形成相关量化指标凝血酶原时间（prothromhin time,PT）、部分活化凝血酶原时间（activated partial thromboplsatin time,APTT）、凝血酶时间（thrombin time,TT）、纤维蛋白原量（fibrinoge,Fbg）、血小板（platelet,PLT）、纤维蛋白降解产物（Fibrinogen degradation products,FDP）以及D-二聚体的动态检测,对比T0期与T1期各项指标的变化。结果：T0与T1比较,置管前后PLT、D-二聚体值有统计学差异（t=2.387,P=0.028;t=2.487,P=0.022）,而PT、APTT、TT、Fbg、FDP统计学差异不明显。结论：①对PICC置管肺癌患者用肝素钠（125 U/ml）稀释液封管是安全的。②PICC置管肺癌患者用肝素钠（125 U/ml）稀释液封管,PLT、D-二聚体值均呈下降趋势,对预防PICC血栓形成有一定影响意义。
Objective：To study the effect of heparin sodium（125 U/ml）for locking on the prethrombotic state in lung cancer patients with peripherally inserted central catheter（PICC）.Methods：Clinical data of 20 lung cancer patients with PICC were randomly selected in our department.Heparin sodium（125 U/ml）was used for locking after PICC being inserted.All parameters in our study including prothromhin time（PT）,activated partial thromboplsatin time（APTT）,thrombin time（TT）,fibrinoge（Fbg）,platelet（PLT）and Ddimer were dynamically monitored 2 times：0-1 d before（T 0）and 2-3 d after（T 1）PICC insertion.Results：Differences in PLT and Ddimer between T 0 and T 1 were significant（t=2.387,P=0.028;t=2.487,P=0.022）.There was no significant difference in PT,APTT, TT,Fbg,FDP between T 1 and T 0.Conclusions：①Using heparin sodium（125 U/ml）for locking is safe for patients with lung cancer after PICC insertion.②Heparin sodium（125 U/ml）for locking can reduce PLT and D-dimer levels of patients with lung cancer after PICC insertion and can prevent venous thrombosis.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2013年第7期726-728,共3页
Journal of Chongqing Medical University
基金
重庆医科大学附属第一医院院内课题资助项目(编号:HLJJ2009-02)
关键词
肝素钠
肺癌
经外周静脉置入中心静脉导管
血栓前状态
heparin sodium
lung cancer
peripherally inserted central catheter
prethrombotic state
