摘要
目的：探讨血栓前状态的检测对外周静脉置入中心静脉导管（Peripherally inserted central catheter,PICC）血栓形成的预警意义。方法：通过随机抽取我科30例PICC置管患者,以2009年6月19日~2010年2月22日的临床检验资料进行统计分析。通过对PICC置管前0~1 d（T0）、置管后2~3 d（T1）、置管后4~11 d（T2）与血栓形成相关量化指标凝血酶原时间（Prothrombin time,PT）、凝血活酶时间（Activated partial thromboplsatin time,APTT）、凝血酶时间（Thrombin time,TT）、纤维蛋白原量（Fibrinogen,Fbg）、纤维蛋白降解产物（Fibrinogen degradation products,FDP）及D-二聚体的动态检测,对比T0与T1、T0与T2、T1与T2,观察各时间段各项指标的变化。结果：T0与T1比较,2组PLT值有显著差异（P〈0.05）,而PT、APTT、TT、Fbg、FDP及D-二聚体则统计学差异不明显;T0与T2比较,PT、APTT、TT、PLT、Fbg、FDP及D-二聚体统计学差异亦不明显;T1与T2比较,PT、APTT、TT、PLT、Fbg、FDP及D-二聚体统计学差异同样不明显。结论：只有PLT在T0与T1时间段具有显著差异,提示置管后2~3 d检测外周血血小板（Plateled,PLT）在PICC血栓形成前具有预警意义。
Objective：Tostudythe earlywarningmeaningofprethrombotic state test before thrombosis caused byPICC. Methods：Clinical data of 30 patients selected randomly in our department during 2009.6.19~2010.2.22 was analyzed retrospectively. All the parameters brought into our study included PT ,APTT,TT,PLT,Fbg,FDP and D-dimer. Every parameter was dynamically detected 3 times,0~1 days before （T0）,2~3 days after （T1）,4~11 days after （T2） PICC inserted. Three values of each parameter were compared in pairwise comparison. Results：The difference of PLT between T0 and T1 was significant （P0.05）. There was no significant difference in PT, APTT,TT,Fbg,FDP and D-dimer between T1 and T0 （P0.05）. Between T0 and T2,T1 and T2,there was no significant difference in all the 7 parameters（P0.05）. Conclusion：As the significant difference in PLT between T0 and T1,PLT test before and 2~3 days after PICC inserted may have great meaning of early warning thrombosis.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2010年第10期1589-1591,共3页
Journal of Chongqing Medical University
基金
重庆医科大学附属第一医院院内课题(编号:HLJJ2009-02)
关键词
血栓前状态
PICC
预警
Prethrombotic state
Peripherallyinserted central catheter
Earlywarningmeaning
