摘要
目的研究β-环糊精(β-CD)及其衍生物对金丝桃素的增溶作用及荧光增强作用。方法通过测定金丝桃素在不同浓度CD衍生物中的溶解度,绘制相溶解度曲线及荧光谱图。结果随着CD浓度的增加金丝桃素的溶解度也增加,荧光强度也随着增强,金丝桃素与交联环糊精包结比为1∶2。结论β-CD及其衍生物对金丝桃素均有增溶作用,其中交联环糊精的增溶效果最为显著,且对金丝桃素具有较强的荧光增强作用。
Objective To study the influence of β-cyclodextrin（β-CD） and its derivatives on solubilization and fluorescence enhancement of hypericin.Methods The phase diagram and fluorogram were obtained by determining hypericin solubility in different concentrations of β-CD and its different derivatives.Results The solubility and fluorescence intensity of hypericin were significantly enhanced by increased CD concentration and hypericin could form an inclusion compound（1∶ 2） with the cyclodextrin polymers（CDP）.Conclusion β-CD and its derivatives all have solubilization enhancing effect on hypericin with CDP showing the most significant effect.Besides,CDP have the strong fluorescence enhancement for hypericin.
出处
《国际药学研究杂志》
CAS
CSCD
2013年第3期369-373,共5页
Journal of International Pharmaceutical Research
关键词
环糊精
金丝桃素
增溶
荧光增强
cyclodextrin
hypericin
solubilization
fluorescence enhancement
