摘要
白藜芦醇是一种天然存在的多酚和植物抗毒素,药理作用广泛,包括抗癌、抗氧化和抗炎作用等。其水溶性差,光稳定性差,首关效应强,导致其生物利用度过低,限制了其应用。研究人员针对提高其生物利用度进行了一系列制剂学研究。该文列举了影响白藜芦醇生物利用度的理化性质和药动学性质,并对有关白藜芦醇的制剂研究进展进行综述,以期为该化合物的进一步开发利用提供参考。
Resveratrol,a naturally occurring polyphenol and phytoalexin,has received significantly attention in recent years due to its vast therapeutic effects including anticancer,antioxidant and anti-inflammatory effects,etc.However,poor pharmacokinetic properties such as low aqueous solubility,low photo-stability and extensive first pass metabolism result in poor bioavailability,which hindering its immense potential.A number of theoretical solutions have been developed to improve the bioavailability of resveratrol.This review enumerates the physicochemical and pharmacokinetic properties that affect resveratrol bioavailability,describes formulations tested for resveratrol administration and identifies future opportunities for resveratrol delivery.
出处
《医药导报》
CAS
北大核心
2018年第3期333-337,共5页
Herald of Medicine
基金
国家自然科学基金资助项目(81202484)
关键词
白藜芦醇
生物利用度
靶向制剂
缓控释制剂
Resveratrol
Bioavailability
Targeted preparation
Sustained-and controlled-released preparation
