摘要
背景血管的通透性主要由跨细胞途径和细胞旁途径两部分组成。在炎症反应过程中，细胞旁途径是增加血管通透性的主要因素。紧密连接（tightiunction，TJ）是细胞旁途径的重要组成部分，破坏它将导致细胞通透性的增加。目的分析TJ的信号机制，更好地理解其保护血管屏障的功能。内容对影响TJ的几个重要的信号通路进行综述，揭示其影响细胞通透性的信息传递和调控作用。趋向TJ的完整性可以抑制水肿液的产生，今后将进一步探索其在炎症性疾病中的具体应用，从而更好地诊断疾病，预测疾病的发生发展及疗效。
Background Vascular permeability is primarily composed of transcellular and paracellular pathways, with the latter being a major contributor to the increasing of vascular permeability in the process of inflammation. Tight junction （TJ） is the important component of paracellular pathways. The destruction of TJ will induce the increasing of vascular permeability. Objective This article is to analyze signaling mechanisms of TJ and to explain its function of protecting blood vessels barriers. Content This article reviewed several important signaling mechanisms which affect the TJ,revealed its information transfer and regulation of cell permeability. Trend The integrity of TJ can restrain the generation of edema fluid and future research will focus on its specific application in inflammatory disease, in order to diagnose better and predict development and therapeutic effect of disease.
出处
《国际麻醉学与复苏杂志》
CAS
2013年第7期655-659,共5页
International Journal of Anesthesiology and Resuscitation
关键词
紧密连接
血管内皮细胞
通透性
信号通路
Tight junction
Vascular endothelial cell
Permeability
Signaling mechanisms
