摘要
糖尿病视网膜病变是成年人低视力和致盲的主要原因。一个合理的体外模型不仅能模拟疾病的发生发展机制,而且能减少经济投入,因此筛选和构建合适的体外模型是研究的关键。论文围绕糖尿病视网膜病变探讨了炎症反应、细胞凋亡、血管功能障碍和神经血管单元的破坏等相关机制,总结了内皮细胞、周细胞、视网膜色素上皮细胞、神经胶质细胞等建立的几种模型,以期为糖尿病视网膜病变机制研究及相应的药物研发提供有益的参考。
Diabetic retinopathy is the leading cause of poor vision and blindness in adults.A reasonable model for diabetic retinopathy can not only simulate its pathogenic mechanism,but also reduce economic investment.Therefore,screening and constructing suitable cell models is the core of research.In this paper,the mechanisms of inflammatory response,apoptosis,vascular dysfunction,and neurovascular unit dysfunction in diabetic retinopathy were discussed.Moreover,several models of endothelial cells,pericytes,retinal pigment epithelial cells,and glial cells were summarized to provide a useful reference for further studies on the mechanism of diabetic retinopathy and the development of relevant drugs.
作者
王娇娇
李苗(综述)
宋宗明(审校)
WANG Jiaojiao;LI Miao(Overview);SONG Zongming(Guidance)(Department of Ophthalmology,Henan Provincial People's Hospital/Henan Eye Hospital/Henan Eye Institute,Zhengzhou 450003,Henan,China)
出处
《山东大学耳鼻喉眼学报》
CAS
2022年第5期93-99,共7页
Journal of Otolaryngology and Ophthalmology of Shandong University
基金
国家自然科学基金(82004426)
中国博士后科学基金(2020M682305)
河南省医学科技攻关计划联合共建项目(LHGJ20190817)
河南省立眼科医院基础研究专项(20JCQN007)。
