摘要
目的:评价血清胱抑素C(Cys-C)的检测在早期肾功能损害诊断中的临床应用。方法:按照肌酐清除率(Ccr)测量值大小将182例肾功能损害患者进行分组,选取67例健康体检者为对照组;酶法检测血肌酐(Scr)、血尿素氮(BUN)、Ccr,颗粒增强散射免疫法检测血清Cys-C的浓度,分析比较各组相关性。结果:各组血清Cys-C值比较差异有显著性(P<0.05),且随着肾功能损害程度的增加,血清Cys-C值显著升高;中、重度肾功能损害及尿毒症组的Scr、Ccr和BUN与健康对照组差异有显著性(P<0.05或P<0.01)。结论:血清Cys-C是反映早期肾功能损害的灵敏诊断指标,可早期判断肾小球滤过功能损害。
Objective：To evaluate the clinical application of the serum cystatin-C （Cys-C）determining in the earIy renal function impairment. Methods：According to the creatinine clearance rate（Ccr）, 182 patients with renaI function impairment were divided into different groups, 67 cases were chosen in the healthy controI group, the serum creatinine （Scr）, bIood urea nitrogen（BUN ）and Ccr were detected by the enzymic method, the chroma of Cys-C was detected by grain enhancement scattering immunifaction, and the correlation analysis was carried out.Results：Serum Cys-C had statisticaI significance with the different groups （P〈 0.05）, and the serum level of Cys-C increase with the renal function impairment, onIy the Scr, Ccr and BUN in the moderate and serious kidney damage groups had statistical significance with the heaIth group （P〈 0.05 or P〈 0.01）. Conclusion：Serum Cys-C is a sensitive indicator in the earIy renal function impairment, which can estimate gIomeruIar fiItration function damage earIy.
出处
《安徽卫生职业技术学院学报》
2013年第3期86-87,共2页
Journal of Anhui Health Vocational & Technical College
关键词
早期肾功能损害
肾小球滤过率
血清胱抑素C
EarIy renal function impairment
GIomeruIar fiItration rate
Serum cystatin - C
