摘要
目的研究肾功能不同损害期患者血清胱抑素C(Scc)浓度变化及其与血清肌酐(Scr)的相关性,并对Scr和Scc在反映肾小球滤过率(GFR)中的应用作一比较。方法根据临床分期将研究对象分为CKD5期,采用免疫比浊法检测120例患者Scc水平,用苦味酸法检测Scr,并进行相关性分析。结果 Scc与Scr呈高度正相关(r=0.78,P<0.01),在肾功能损伤早期,Scc比Scr更敏感,两者差异有统计学意义(P<0.05)。结论 Scc是一种比Scr更好的反映肾小球滤过功能的指标,能反映CKD不同阶段中肾脏滤过功能的损害程度。
Objective To investigate the change of serum cystatin （Scc） and its relation with creatinine（Scr） in different stages of renal function impairment and to compare their application value reflecting glomerular filtration rate（GFR）.Methods According to the clinical staging of chronic kedney diseases（CKD）,120 patients were divided into five groups and determined serum Scc by immunoturbidimetry and Scr by picric acid method.Results The significant positive correlation was observed between Scc and Scr （r=0.78,P0.01）.In the early stage of renal function impairment,Scc was more sensitive than Scr with statistic difference（P0.05）.Conclusion Scc is superior to Scr as a maker reflecting glomerular filtration function,which may show the degree of renal impairment in the different stages of CKD.
出处
《检验医学与临床》
CAS
2010年第19期2083-2084,共2页
Laboratory Medicine and Clinic
