摘要
目的:探讨视黄醇结合蛋白(RBP)检测对肾脏功能早期损害的应用价值。方法:我院糖尿病科及高血压病专科住院及门诊病人标本(糖尿病均为2型糖尿病),共926份,包括血液、尿液(晨尿),对所有血液标本进行RBP、胱抑素C(CysC)、β2-微球蛋白(β2-M)、尿素氮(BUN)、肌酐(Cr)的检测;对RBP结果在70～120mg/L之间的患者进行尿液的RBP、β2-M、尿微量白蛋白(U-Alb)、Cr的检测,并进行统计学分析。结果:RBP测定结果正常时,CysC、β2-M、Cr、BUN都在正常范围之内,当RBP出现轻度升高时,CysC、β2-M同步升高,并与对照组有显著差异,而BUN、Cr均无明显变化,但随着前种指标的明显升高,BUN、Cr也有着相应的改变,但其程度不显著。尿液标本中,变化最显著的依次为RBP、β2-M、CysC、Alb,而Cr几乎无变化。结论:在糖尿病、高血压等疾病的早期,引起肾小球滤过率或肾血流量降低时,致使血液中RBP蓄积而使之浓度升高,其敏感性远高于Cr、BUN,与CysC、β2-M相当。在出现明显肾脏损害时,其升高的程度也与CysC相当,高于β2-M(两组比较P<0.05),当造成早期近端肾小管损伤时,RBP、CysC、β2-M在尿液中的浓度升高十分明显,而尿液中的肌酐几乎无变化,且RBP升高程度大于β2-M、CysC、Alb等(P<0.05)。
Objective：To investigate the detection of RBP value in renal dysfunction.Methods：Diabetes and hypertension samples（diabetes are type 2diabetes）,a total of 926copies,including blood,morning urine.All blood samples were detected RBP,CysC,β2-M,BUN,Cr.Then RBP in 70～120mg/L of patients were detected for the urine RBP,β2-M,Alb,Cr testing and analyzed statistically.Results：Results of RBP determination were normal,CysC,β2-M,Cr,BUN were within the normal range,when RBP rises,CysC,β2-M simultaneously increased.Compared with the control group,there were significantly difference.The BUN,Cr were no significant changes,but RBP increased significantly,BUN,Cr also had a corresponding change,but the extent is not significant.The urine,the order of the most significant change was RBP,β2-M,CysC,Alb.The Cr was almost unchanged.Conclusion：Diabetes mellitus,hypertension and other diseases early,caused glomerular filtration rate or renal blood flow decreasing,resulting in accumulation of blood in the RBP concentration,which sensitivity is much higher than Cr,BUN,and CysC,β2-M.In the event of significant kidney damage,its higher degree of CysC was also quite higher than theβ2-M（P0.05）.When the cause of early proximal tubular injury,RBP,CysC,β2-M in urine fluid concentration is obvious,but Cr had almost no change,and elevated level of RBP was higher thanβ2-M,CysC,Alb（P0.05）.
出处
《医学理论与实践》
2010年第8期905-907,共3页
The Journal of Medical Theory and Practice
