摘要
目的探讨血清β2微球蛋白(β2-MG)及血清胱氨酸蛋白酶抑制剂C(CysC)在评估高胆红素血症新生儿肾功能中的价值。方法收集2012年1月至2012年10月符合新生儿高胆红素血症诊断标准的新生儿60例,根据胆红素水平分为轻度组(总胆红素<256.50μmol/L)及中重度组(总胆红素≥256.50μmol/L),另选年龄、性别相匹配的正常足月新生儿34例作为对照组,测定比较各组新生儿血清β2-MG、CysC及肌酐(Cr)、尿素氮(BUN)等。结果两组高胆红素血症新生儿的血清β2-MG及CysC高于对照组,血清Cr、BUN低于对照组,差异均有统计学意义(P均<0.05)。治疗后,高胆红素血症新生儿血清β2-MG及CysC低于治疗前,但仍高于对照组,差异均有统计学意义(P均<0.05)。结论新生儿高胆红素血症对新生儿肾功能有不同程度的损害,经积极治疗后可有所恢复。
Objectives To explore the application of serum β2-microglobulin （β2-MG） and cystatin C （CysC） to eva-lu- ate renal function in patients with neonatal jaundice. Metheds Sixty neonates with hyperbilirubinemia from January 2012 to Octorber 2012 in pediatric department were selected and divided into mild group （bilirubin〈256.51μmol/L） and moderate severe group （bilirubin≥256.5μtmol/L） according to the level of bilirubin. Thirty-four full-term, age-and sex-matched neo-nates were chosen as healthy controls. Serum β2-MG, CysC, creatinine （Cr） and blood urea nitrogen （BUN） were measured. Results Serum ~2-MG and CysC in neonates with hyperbilirubinemia were significantly higher than those in healthy con- trois （P〈0.05）, meanwhile, serum Cr and BUN were significantly lower than those in healthy controls （P〈0.05）. After treat- ment, serum β2-MG and CysC of neonates with hyperbilirubinemia were significantly decreased, but still higher than those in healthy controls （all P〈0.05）. Conclusions The neonates with hyperbilirubinemia have the varying degrees of impaired renal function. However, the damage can partially be recovered after treatment.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2013年第6期511-513,共3页
Journal of Clinical Pediatrics
基金
包头市卫生基金项目(No.2012S2006-06-03)
