摘要
目的：分析多巴胺联合多巴酚丁胺对窒息后肾损害新生儿靶器官功能指标及分子指标的影响。方法：2012年8月-2015年8月湖北省鄂州市中心医院收治的40例窒息后肾损害新生儿随机分为观察组及对照组,对照组接受常规治疗,观察组接受常规疗法＋多巴胺＋多巴酚丁胺治疗,对比两组治疗后肾血流参数、尿微量蛋白及血清肾功能相关指标水平差异。结果：观察组治疗后Vmax、Vmin、TAMX水平高于对照组,RI、PI值低于对照组（P〈0.05）;尿液α1-MG、Alb、RBP、Ig G、TRF水平均低于对照组（P〈0.05）;血清BUN、Cr、ET-1、Cystatin C水平均低于对照组（P〈0.05）。结论：多巴胺联合多巴酚丁胺是治疗新生儿窒息后肾损害的可靠方式,在优化肾血流及肾功能方面均有积极作用。
Objective： To analyze the effect of dopamine combined with dobutamine on target organ function indicators and molecular indicators in children with renal damage after neonatal asphyxia. Methods： A total of 40 children with renal damage after neonatal asphyxia were randomly divided into observation group and control group,control group received conventional therapy,observation group received conventional therapy ＋ dopamine ＋ dobutamine therapy,and then differences in levels of renal blood flow parameters,urine trace proteins and serum renal function-related parameters were compared between two groups after the treatment. Results： Vmax,Vmin and TAMX levels of observation group after treatment were higher than those of control group while RI and PI values were lower than those of control group（ P〈0. 05）; urine α1-MG,Alb,RBP,Ig G and TRF levels were lower than those of control group（ P〈0. 05）; serum BUN,Cr,ET – 1 and Cystatin C levels were lower than those of control group（ P〈0. 05）. Conclusions：Dopamine combined with dobutamine is a reliable way to treat renal damage after neonatal asphyxia,and plays a positive role in the optimizing renal blood flow and renal function.
出处
《海南医学院学报》
CAS
2016年第18期2112-2114,共3页
Journal of Hainan Medical University
基金
湖北省自然科学基金项目(2014CBF12)~~
关键词
新生儿窒息
肾损害
多巴胺
多巴酚丁胺
Renal damage after neonatal asphyxia
Dopamine
Dobutamine
