摘要
目的：比较拉西地平与尼群地平治疗中，老年高血压病的疗效。方法：高血压病人共１７０例，分为治疗组８８例［男性７２ 例，女性１６例；年龄（６４±ｓ９） ａ］和对照组 ８２例［男性 ７０ 便，女性 １２例；年龄（６３±９）ａ］。治疗组给拉西地平４ ｍｇ，ｐｏ，ｑｍ。对照组给尼群地平 １０ ｍｇ，ｐｏ， ｔｉｄ。 ２组均共服 １ｍｏ。结果：拉西地平组治疗１ｍｏ后，ＳＢＰ／ＤＢＰ从（２２．６／１３．８ ±１． ９ ／０． ８） ｋＰａ降至（ １８ ／１１． ０ ± ３／０． ９） ｋＰａ（ Ｐ＜０．０１）；尼群地平组分别为（２２．４ ／１３．６±１． ５／０． ７） ｋＰａ（ １９． ０ ／１２． ０± １． ８ ／０．９） ｋＰａ（ Ｐ＜０． ０１）； ２组组间比较，差别均有显著意义（ Ｐ＜ ０． ０５和Ｐ＜０．０１）。结论：拉西地平治疗中、老年高血压降压疗效优于尼群地平组。
AIM: To compare the effects Of lacidipine and nitrendipine in Patients with hypertension. METHODS: One hundred and seventy patients with hypertension were divided into: lacidipine group [M.72, F 16, age (64 +- s 9) a] received lacidipine 4 mg po, qm, for 1 mo and nitrendipine group [M 70, F 12, age (63 +- 9) a] received nitrendipine 10 mg, po, tid, for 1 me. RESULTS: After treatment of 1 mo, the SBP /DBP was reduced from (22. 6 / 13.8+- 1. 9/0. 8) kPa to (18/11. 0 +- 3/0. 9) kpa in lacidipine group (P < 0. 01 ); and nitrendipine group was reduced from (22. 4/13. 6 +- 1. 5/0. 7) kpa to (19. 0/12. 0 +- 1. 8/0. 9 )kParespectively(P < 0.01), there were significant difference between the two groups (P<0.05, P<0.01 ). CONCLUSION: lacidipine yield a more potent hypotensive effect than nitrendipine.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2000年第2期102-104,共3页
Chinese Journal of New Drugs and Clinical Remedies
