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血清游离脂肪酸、TNF-α及IL-6与2型糖尿病神经病变的关系 被引量:12

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摘要 目的探讨血清游离脂肪酸、TNF-α、IL-6与2型糖尿病神经病变(DN)的关系。方法 2型糖尿病患者92例,根据双下肢肌电电生理检查分为2型糖尿病神经病变组(DN组)40例,2型糖尿病非神经病变组(NDN组)52例,以及健康对照组(NC组)40例。每组均检测血压、体重,计算体重指数(BMI)、糖化血红蛋白(HbA1c)、尿微量蛋白/肌酐(尿A/C)、三酰甘油(TG)、总胆固醇(TC)、空腹血糖以空腹胰岛素及C肽、血清游离脂肪酸(FFA)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)。结果 DPN组与非DPN组比较血清FFA、TNF-α、IL-6含量显著升高(P<0.01);糖尿病神经病变危险因素分析:病程、尿A/C、HbA1c、HOMA-IR、TNF-α、FFA、IL-6进入回归方程。炎性因子TNF-α、IL-6与血游离脂肪酸水平呈正相关(P<0.05)。结论血游离脂肪酸、TNF-α、IL-6是NC的危险因素。
出处 《河北医药》 CAS 2013年第12期1787-1789,共3页 Hebei Medical Journal
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