摘要
本文对小鼠腹腔多房棘球蚴(泡球蚴)早期和晚期感染分别进行丙硫咪唑和中药消包粉的实验治疗,药物分为单用西药、单用中药和中西药并用三组,均采用药饵口饲法,考核药效依据主要是小鼠腹腔泡球蚴湿重均值和抑制率、泡球蚴病理分级率和超微结构等,然后进行t检验和X^2检验,计算P值。三组治疗早期感染小鼠均有阻抑泡球蚴增殖生长之效(P<0.01),中药消包粉虽显抗泡球蚴的作用,但其药效不及丙硫咪唑,中西药并用亦未明显起到中药增强西药之效,然超微结构所见却显较重的损害程度。三组治疗晚期感染小鼠的腹腔泡球蚴抑制率,经t检验无显著差异(P>0.05),表明三组之间无阻抑泡球蚴增长之差别。泡球蚴病理分级率按早期和晚期感染小鼠的药效考核,虽均为单用西药组>中西药并用组>单用中药组,但经x^2检验均无显著差异(P>0.05),提示病理分级率用以考核药效尚待继续研讨。
In the present study, the early and advanced stages of mice intraperitoneal alveococcus infection were respectively treated with albendazole and Chinese herbs ' anti-echinococcus powder'. The drugs were divided into three groups of single albendazole, single Chinese herbs and combination of the two. The drug-bait method was orally administered in all mice. Three groups for treating early-stage infected mice had the effects of inhibiting alveococcus proliferation and growth (P<0.01). Although the Chinese drugs showed anti-echinococcus action, their effect was not only less than albendazole but also without obvious action to strengthen albendazole. However according to the findings of ultramicroscopical structure, the degree of alveococcus damage showed more severe in the mice of the combined-drug group. The drugs of three groups were also used to treat advanced-stage infected mice, in which the wet weight mean of intraperitoneal alveococcus had no marked difference by t test (P>0.05), showing similarity of inhibiting alveococcus proliferation and growth. The percentage of alveococcus pathological Ⅰ- or Ⅱ-grade was used to evaluate the curative effects of three groups in early- and advanced-stages infected mice, and their effective orders were single albendazole > the combined drugs > single Chinese herbs. But there was no obvious difference by x2 test (P > 0.05), so the percentage of pathological grade remained to be continuously studied for a basis of evaluating the drug efficacy.
出处
《地方病通报》
1991年第3期1-6,共6页
Endemic Diseases Bulletin
关键词
多房棘球蚴
丙硫咪唑
中医药疗法
Larval Echinococcus multilocularis (alveococus)
Chemotherapy
Albendazole
Traditional Chinese medicine
