摘要
目的:评价中医药治疗幼年类风湿关节炎的临床随机对照试验的质量及中医药治疗幼年类风湿关节炎的证型和治则。方法:通过手动和计算机检索获得2002—2012年发表的有关中医药治疗幼年类风湿关节炎的临床随机对照试验(RCTs)文献,按照中医药临床随机对照试验报告规范对文献的质量进行评价及中医药治疗幼年类风湿关节炎的证型和治则进行统计分析。结果:共检索出中医药治疗幼年类风湿关节炎符合要求的RCTs文献36篇,无一篇文献题目体现随机内容,无一篇采用盲法,21篇提及随机分配方法,24篇采用阳性对照,无一篇文献提供样本量估计,18篇进行了基线资料的统计分析。所纳入的文献中,所采用的诊断标准不统一,采用西医诊断标准切有明确出处的为18篇,其中仅2篇既采用西医又有中医诊断标准。11篇为单证型分类,22篇为多证型文献,各证型中以风湿热痹型(27%)和风湿寒痹型(20%)为多见,治则的统计可以看出除湿通络法出现的频次最多,占22%,其次依次为祛风清热法、温经散寒法、活血化瘀法。结论:中医药治疗幼年类风湿关节炎的RCTs文献数量较少,同时进一步规范其辨证分型及疗效评价标准,质量需进一步提高。
Objective ： To evaluate the quality of the randomized controlled trials, syndrome types and principles of the treatment which are about the traditional Chinese medicine in the treatment of Juvenile rheumatoid arthritis. Methods ： The literatures which are clinical randomized controlled trials （RCTs） in 2002 - 2012 Chinese medicine in the treatment of juvenile rheumatoid arthritis were collected through manual and computer searches. According to Chinese medicine clinical randomized controlled trials report specification, the quality of the literature, summary and statistical analysis on the syndrome types and principles of traditional Chinese medicine in the treatment of juvenile rheumatoid arthritis were studied. Results：A total of 36 RCTs were retrieved. No literature reflected the random, no one was blind designed, 21 mentioned random allocation method, 24 used positive control, no one literature provided sample size estimates, 18 carried out a statistical analysis of the baseline data. The diagnostic criterion used was not unified. 18 used Western diagnostic criteria and had a clear provenance, only two of them had both Western medicine and TCM diagnostic criteria. 11 used single syndrome type classification, 22 used multiple syndrome types. Heat Bi -type （27%） and cold Bi -type （20%） were more common. The frequency of eliminating dampness and dredging collaterals was the highest （22%）. The second was method of dispelling wind and clearing heat, warming meridians and dispersing cold and activating blood circulation and resolving blood stasis. Conclusions ： There was a small number of RCTs of Chinese medicines in the treatment of juvenile rheumatoid arthritis, and it needs to further regulate the syndrome type and treatment evaluation standards, and RCTs literature quality needs further improvement.
出处
《中华中医药学刊》
CAS
2013年第6期1395-1397,共3页
Chinese Archives of Traditional Chinese Medicine
关键词
幼年类风湿关节炎
中医证型
治则
随机对照试验
质量评价
juvenile rheumatoid arthritis
TCM syndromes
principles of treatment
randomized controlled trials
quality assessment
