摘要
目的探讨黑药膏联合红外偏振光治疗幼年特发性关节炎(juvenile idiopathic arthritis,JIA)的临床疗效及安全性。方法选取2024年1月至2025年1月在乌鲁木齐市第一人民医院(乌鲁木齐儿童医院)接受治疗的46例JIA患儿作为研究对象;采用随机数字表法分为观察组(n=23)与对照组(n=23)。对照组接受常规西药治疗,包括口服非甾体抗炎药物及甲氨蝶呤治疗;观察组在对照组基础上加用黑药膏与红外偏振光联合治疗。主要疗效指标为幼年关节炎疾病活动性评分(juvenile arthritis disease activity score,JADAS)-27,次要指标包括C反应蛋白(C-reactive protein,CRP)、红细胞沉降率(erythrocyte sedimentation rate,ESR)及不良反应发生率;分别于治疗前、治疗1周及治疗6个月进行评估。结果治疗后,两组患儿的JADAS-27评分均较治疗前显著降低(P<0.05)。治疗6个月,观察组患儿的JADAS-27评分显著低于对照组(P<0.05)。治疗后,两组患儿的ESR、CRP均较治疗前显著改善(P<0.05)。结论黑药膏联合红外偏振光治疗JIA疗效显著,可显著改善患儿疾病活动度,安全性良好。
Objective To investigate the clinical efficacy and safety of black ointment combined with infrared polarized light in the treatment of juvenile idiopathic arthritis(JIA).Methods A total of 46 children with JIA treated in the First People's Hospital of Urumqi(Children's Hospital of Urumqi)from January 2024 to January 2025 were selected as subjects.They were divided into observation group(n=23)and control group(n=23)by a random number table.The control group received conventional Western medicine treatment,including oral nonsteroidal anti-inflammatory drugs and methotrexate therapy.The observation group received additional treatment with black ointment combined with infrared polarized light on the basis of control group.The primary efficacy endpoint was the juvenile arthritis disease activity score(JADAS)-27,while secondary endpoints included C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),and incidence of adverse reactions.Assessments were conducted before treatment,at 1 week post-treatment,and at 6 months post-treatment.Results After treatment,the JADAS-27 scores of both groups of pediatric patients were significantly reduced compared to pre-treatment levels(P<0.05).At 6 months post-treatment,the JADAS-27 scores of observation group were significantly lower than those of control group(P<0.05).Both groups showed significant improvements in ESR and CRP levels after treatment compared to pre-treatment levels(P<0.05).Conclusion The combination of black ointment and infrared polarized light therapy demonstrates significant efficacy in JIA,markedly improving disease activity with favorable safety profiles.
作者
孟广雨
曹杰
米尔扎提·海维尔
苏丽
MENG Guangyu;CAO Jie;MIERZHATI·Haiweier;SU Li(Department of Rheumatology and Immunology,the First People's Hospital of Urumqi(Children's Hospital of Urumqi),Urumqi 830002,Xinjiang,China;Department of General Surgery,Sixth Affiliated Hospital of Xinjiang Medical University,Urumqi 830002,Xinjiang,China;Traditional Chinese Medicine Specialty Clinic,Affiliated Tumor Hospital of Xinjiang Medical University,Urumqi 830011,Xinjiang,China)
出处
《中国现代医生》
2026年第5期58-62,共5页
China Modern Doctor
基金
乌鲁木齐市中医药科技创新项目(ZYYMS-06)。
关键词
幼年特发性关节炎
黑药膏
疾病活动度评分
红外偏振光
Juvenile idiopathic arthritis
Black ointment
Disease activity score
Infrared polarized light
