摘要
目的 :增加甘草酸的保肝作用。方法 :在隋性溶剂中将甘草酸与磷脂酰胆碱形成配位体口服。结果 :甘草酸形成脂质配位体后从水溶性变为脂溶性 ,理化性质 (红外、紫外光谱、高效液相等 )无明显改变 ,抗肝损作用明显增加。结论 :口服甘草酸脂质配位体的抗肝损作用明显优于甘草酸。
OBJECTIVE:in order fo raise the liver protecve activity of oral glycyrrhizin.METHOD:The lipophilic complexe of glycyrrhizin was preparated via glycyhrhizim and phospholipids in the presence of inert solvent.RESULTS:The increasing liposolubility of glycyrrhizicnphos phatidylcho line comple and physico chemical proper ties(IR,UV,HPLC),no significane change was found in the aspeet.Glycyrrhizicnphosphatidylcho line complex on Gal induced hepatic injury is suprior to glycyrrhicic.CONCLUSION:The results demonstrate that the liver protecve action of glycyrrhizicnphosphatidylcho line complex on Gal in duced hepatic injary is suprior to glycyrrhicic.
出处
《中国现代应用药学》
CAS
CSCD
2000年第3期241-242,共2页
Chinese Journal of Modern Applied Pharmacy
