摘要
目的评价a-硫辛酸联合甲钴胺对糖尿病周围神经病变治疗疗效的临床观察。方法收集糖尿病周围神经病变患者共75例,控制血糖后,给予硫辛酸300～450 mg联合甲钴胺500μg分别加液体中静点,1次/d,疗程10～12 d,获得数据进行统计学分析,并记录治疗过程中出现的不良反应。结果治疗后临床症状的改善,其中显效有20例(占26.7%),有效共39例(占52%),无效为16例(占21.3%),总有效率(达到78.7%)。治疗后下肢震动感觉阈值(包括双脚趾、双足背)与治疗前相比,均明显下降,差异有统计学意义(P<0.05)。且治疗过程中均未出现明显不良反应。结论α-硫辛酸联合甲钴胺治疗糖尿病周围神经病变的疗效显著,除了明显改善临床症状外,尚有降低震动感觉阈值,具有临床应用价值。
Objective To observe the clinical efficacy of a -lipoic acid combined with mecobalamin in the treatment of type 2 diabetic peripheral neuropathy. Methods All 75 cases of DPN were received intravenous infusion α -lipoic acid 0.3-0.45 g combined mecobalamin 500 μg, once a day, course of 10-12 days. The dates were analyzed. Record the adverse reactions during treatment. Results The clinical efficacy of the experimental group, there were 20 cases of excellent （26.7 % ）, 39 cases of effective（52 % ）, 16 cases of invalid（21.3 % ） total efficiency of the group was 78.7% . The vibration perception threshold （VPT） of experimental group was significantly decreased after treatment （P 〈 0.05 ）. Conclusion α-lipoic acid synergistically combined with mecobalamin is effective for type 2 diabetic peripheral neuropathy and lower the vibration perception threshold（VPT ） significantly, have clinical application value.
出处
《中国医药科学》
2013年第10期180-181,198,共3页
China Medicine And Pharmacy
关键词
2型糖尿病
糖尿病周围神经病变α-硫辛酸
甲钴胺
Diabetes mellitus type 2
Diabetic peripheral neuropathy
α -lipoic acid
Mecobalamin
