摘要
目的使用行为学及事件相关电位（ERP）技术探讨注意缺陷多动障碍（ADHD）患儿数学认知功能受损的神经机制。方法2012年7至10月在苏州大学附属第三医院门诊就诊的27例ADHD患儿（ADHD组）及29名年龄、性别相匹配的健康儿童作为对照组，采用20以内加、减、乘法计算模块刺激记录行为学，使用BESA软件提取ERP并进行组间比较。结果（1）行为学：加、减、乘法计算的反应时间ADHD组均明显长于对照组[（949±144）比（829±166）ms，（981±129）比（856±170）ms，（944±136）比（825±172）ms，均P〈0．05]，正确率[肘（Q1，Q3）]则均低[0．80％（0．72％，0．88％）比0．90％（0．85％，0．96％），0．78％（0．64％，0．85％）比0．90％（0．84％，0．93％），0．86％（0．74％，0．92％）比0．93％（0．90％，0．98％），均P〈0．05]。（2）ERP：ADHD和对照组在额部均产生明显的N2波，F3、Fz导联ADHD加、减、乘法波幅均明显低于对照组[F3：（一3．5±5．2）比（一6．7±3．5）μV、（一3．8±4．0）比（一7．4±4．5）μV、一5．8（一7．6，1．6）比一6．4（一10．3，一4．9）μV，Fz：（一4．3±6．4）比（一7．4±4．2）μV、（一5．0±5．4）比（一7．9±4．6）μV、一5．2（一9．7，一0．6）比一7．9（一10．5，一5．1）μV，均P〈0．05]，减法计算在F3、Fz、F4导联ADHD组潜伏期均长于对照组[（328±36）比（307±27）ms，（331±35）比（311±30）ms，325（307，354）比309（280，330）ms，均P〈0．05]。ADHD和对照组在加及乘法的潜伏期上差异均无统计学意义（均P〉0．05）。结论ADHD患儿抑制无关信息及注意控制的能力较弱，在解决加减乘法的计算题时存在计算认知功能的损害，在选择最佳策略完成认知任务中存在缺陷。
Objective To explore the mathematics cognitive function of children with attention deficit hyperactivity disorder and explore neural mechanisms with event-related potential （ERP）. and behaviors. Methods Behavior data and ERP elicited by performing mental calculation tasks were recorded in 27 children with ADHD and 29 normal controls from July to October 2012 at Third Affiliated Hospital of Soochow University. The differences of behaviors and N2 component of ERP were compared and analyzed. Results The reaction time of the children with ADHD were longer than the control group in addition, subtraction and multiplication（ （949 ± 144）vs（ 829± 166） ms, （981 ± 129）vs（856 ± 170） ms, （944±136） vs（ 825 ± 172）ms, all P 〈 0. 05 ）. While the correct rate were less than normal control in all three arithmetic operations （0. 80% （0. 72% , 0. 88% ） vs 0. 90% （0. 85% ,0. 96% ） ,0. 78% （0. 64% ,0. 85% ） vs 0. 90% （0. 84% ,0. 93% ） ,0. 86% （0. 74% ,0. 92% ） vs 0. 93% （0. 90% ,0. 98% ） ,all P 〈0. 05）. N2 component could be elicited by all subjects in forehead. The amplitude of N2 of children with ADHD were significantly lower than control group in all three arithmetic operations at left frontal （ F3 ： （ - 3.5 ± 5.2） vs （ - 6. 7± 3.5）μV, （-3.8±4.0） vs （-7.4±4.5）μV,-5.8（-7.6,1.6）vs -6.4（-10.3,-4.9）μV, allP〈0.05）andFz （（-4.3±6.4） vs （ -7.4±4.2）μV, （-5.0±5.4） vs （-7.9±4.6）μV, -5.2 （ -9. 7, -0. 6） vs -7. 9（ - 10. 5, -5.1 ） txV, all P 〈0. 05） ,the latency of ADHD group were prolonger than controls in subtraction operations at right and left frontal （ （ 328 ± 36 ） vs （ 307± 27 ） ms, 325 （ 307, 354）vs309（280, 330）ms） and frontal electrodes（（331±35） vs （311±30）ms, all P〈0.05）. In addition and multiplication operations, there was no significant difference in latency （all P 〉 0. 05 ）. Conclusions The children with ADHD have weak capacities of inhibition irrelevant information and paying attention to control. Their deficits in mental arithmetics may be due to the difficulties of selecting the best strategy during cognitive tasks.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2013年第20期1555-1558,共4页
National Medical Journal of China
基金
国家自然科学基金（30870868、81101018）
关键词
注意力缺陷障碍伴多动
认知
诱发电位
Attention deficit disorder with hyperactivity
Cognition
Evoked potentials
