摘要
目的探讨不同年龄组学龄期儿童静息态fMRI的特征，研究学龄期儿童认知功能发展变化特点。方法将29名正常学龄期儿童根据年龄分为3组（8岁组10名、10岁组10名、12岁组9名）进行静息态蹦RI扫描，采用局部一致性（ReHo）作为测量指标。结果10岁组与8岁组、12岁组与10岁组及12岁组与8岁组比较发现颞上回（Z=2．83、Z=3．21）、颞中回（Z=3．74、Z=3．19、Z=4．26）、颞下回（Z：3．01）以及豆状核（Z=3．31）等区域的ReHo值增高；12岁组与10岁组、12岁组与8岁组比较发现额上回（Z=3．21）额中回（Z=3．19、Z=3．22）及额内侧回（Z=3．15）、舌回（Z=3．43）以及小脑（Z=3．11、Z=2．97）等区域ReHo值均增高；12岁组与10岁组比较发现扣带回区域（Z=3．45）以及12岁组与8岁组比较发现楔前叶（Z=2．95）、后扣带回（Z=2．64）等区域的ReHo值增高。结论随着年龄增长，正常儿童的执行控制功能、注意调节、视觉空间整合以及静息态时的默认网络功能逐渐完善。
Objective To investigate the characteristics of cognitive development in elementary school children using rest-fMRI methods. Methods Twenty-nine normal school children were divided into three groups according to their ages （8 , 10 ＆ 12 years old） and received the resting-state fMRI scans. A regional homogeneity （ReHo） approach was used to analyze blood oxygen level-dependent fMRI （BOLD- fMRI） data in resting state. The fMRI data were processed with software SPM2 and REST 1.2. Results Compared with younger groups （10 vs 8, 12 vs 10, 12 vs 8 ）, the elder groups showed more increases in superior temporal gyrus（Z =2. 83, Z = 3.21 ）, middle temporal gyrus（Z = 3.74, Z = 3. 19, Z = 4. 26）, inferior temporal gyms（ Z = 3.01 ） and lentiform nucleus （ Z = 3.31 ） . In addition, the ReHo differences were demonstrated in superior frontal gyrus （ Z = 3.21 ）, middle frontal gyrus （ Z = 3.19, Z = 3.22 ）, medial frontal gyrus （ Z = 3.15 ）, lingual gyrus （Z = 3.43 ） and cerebellum （ Z = 3.11, Z = 2. 97） increased more in 12 years old group （12 vs 10, 12 vs 8）. And the precuneus （Z = 2.95 ）and posterior cingutate （Z = 2. 64 ） had increasing ReHo values with the age growth （ 12 vs 8）. Conclusion The function of execution control, accommodation of attention, visual spatial integration and default mode network became gradually developed with increasing age.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2009年第19期1313-1317,共5页
National Medical Journal of China
基金
国家自然科学基金（30870868）
苏州大学医学发展基金（EE12461）
关键词
功能磁共振成像
儿童
发展
认知
静息态
局部一致性
Magnetic Resonance Imaging
Child
Cognition
Development
Resting state
Regional homogeneity
