摘要
采用小鼠抗大鼠Thy1.1单克隆抗体复制大鼠系膜增生性肾炎模型 ,分为益肾活血泄浊汤治疗组、模型组和正常组。每周测定大鼠 2 4h尿蛋白及尿潜血 ,于第 2、5、8周时测定血清白蛋白、肌酐及尿素氮 ,结束时测定血液流变学 ,并进行免疫荧光、光镜及电镜观察。结果表明 :与病理组结果相比 ,治疗组各项指标均有显著性差异 (P <0 .0 5～P <0 .0 1) ,形态学观察也显示治疗组较病理组损害减轻。提示益肾活血泄浊汤能够明显保护病鼠肾功能 ,有效防止血液粘度升高 。
rats were made into the MsPGN model by injection of Thy1.1 monoclonal anti body and randomly divided into three groups, the treatment group (treated by Decoction of BuShenHuoXueXieZhuo), the control group and normal group. 24 hour urinary protein contents and hematuria were determined every week, while blood urea nitrogen (BUN), albumin (ALB) and creatinine (CRE) were detected at week 2, 5, and 8. The blood rheology was tested by the end of experiment. At the same time, the pathological changes of MsPGN were also observed through light, immunofluorescent and electronic microscopy. Results: the MsPGN rats showed serious proteinuria, hematuria, abnormal blood rheology and various indexes change in blood biochemistry, but these indexes in the treatment group got markedly improved compared with those of the control group( P<0.05～P <0.01). The light, electronic and immunofluoresent microscopic examination all showed that the pathologic changes in treatment group were less than that of the control. The results showed the Decoction of BuShenHuoXueXieZhuo could markedly protect renal function, alleviate blood hypercoagulability and delay the progression of glomerular fibriosis and sclerosis.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2000年第3期16-19,共4页
Journal of Beijing University of Traditional Chinese Medicine
基金
国家自然科学基金! (No .3 95 70 893 )
关键词
肾小球肾炎
益肾活血泄浊汤
中医药疗法
MSPGN
Mesangial proliferative
Glomerulonephritis
Renal function
Decoction of BuShenHuoXueXieZhuo
Blood rheology
Pathologic changes
