摘要
本实验根据Border方法复制膜性肾小球肾炎模型。实验发现:实验性膜性肾小球肾炎的血浆和肾组织的脂质过氧化物(LPO)浓度显著升高,而全血和肾组织的超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活性明显降低,提示实验性膜性肾小球肾炎存在由活性氧所致的肾组织脂质过氧化损伤,其抗氧化能力降低。用川芎嗪进行治疗,减轻蛋白尿,改善肾功能,提高肾组织和血中SOD和GSH-Px活性,降低脂质过氧化物的含量,从而改善肾脏病变的程度。
Experimental membranous glomerulonephritis(MGN) in Japanese white rabbits was induced by administration of C-BSA according to Border's method. The results showed that the lipid peroxides(LPO) content in plasma and renal cortex were significantly increased compared with that in the controls. On the other hand, the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-px) in whole blood and renal cortex were significantly reduced compared with that in the controls. The results suggested that experimental MGN existed a mechanism of cellular injury manifested as lipid peroxidation in biomembrane, and such injury might be related to toxic effects of reactive oxygen on biomembrane. Tetramethylpyrazine was used to treat experimental MON. The results showed that the drug might have reduced the amount of proteinuria and the extent of lipid peroxidative injury. At the same time, the drug might haod raised the activities of SOD and GSH-px, and improved the lesion ot some extent. It is suggested that tetramethylpyrazine had the effect of anti-lipid peroxidative injury.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1991年第3期229-232,共4页
Chinese Journal of Pathophysiology
基金
国家中医药管理局青年中医科学研究基金
关键词
肾小球肾炎
过氧化脂质类
病理学
Glomerulonephritis
Lipid peroxides
Superoxide dismutase
Glutathione peroxidase
Rabbits
