摘要
目的:探讨野黄芩苷对人舌鳞癌Tca8113细胞中survivin和caspase-8表达的影响。方法:不同浓度的野黄芩苷处理体外培养人舌鳞癌Tca8113细胞,采用western-blot法检测survivin及caspase-8蛋白表达。结果:80、120、160μg/ml的野黄芩苷作用于Tca8113细胞48h后,随着药物浓度的增加,survivin蛋白的表达依次递减(P<0.05);caspase-8蛋白的表达依次递增(P<0.05)。结论:野黄芩苷能调节survivin和caspase-8的表达。
Objective： To investigate the effects of scutellarin on survivin and caspase expression in human tongue squamous cell carcinoma Tea-8113 Cells. Methods： Tea-8113 ceils were cultured in the presence of seutellarin at 80,120 and 160μg/ml respectively for 48 hours. Western blot was used to detect survivin and caselase-8 protein expression in the cells. Results： Scutellarin decreased survivin protein expression while increased caspase-8 protein expression in a dose-dependant manner（ P 〈 0.05 ）. Conclusion： Scutel- latin may regulate survivin and caspase-8 protein expression in Tea-8113 cells.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2013年第3期372-374,共3页
Journal of Practical Stomatology
