摘要
目的：探讨VEGF在慢性宫颈炎、宫颈上皮内瘤变（CIN）及浸润性宫颈癌（ICC）中的表达，旨在提高宫颈上皮内瘤变及浸润性宫颈癌的诊断率。方法：采用免疫组化SP法检测40例慢性宫颈炎、30例CINⅠ～Ⅱ、25例CINⅢ以及30例ICC病例中VEGF的表达。结果：慢性宫颈炎组织、CINⅠ～Ⅱ组织中很少表达VEGF，在CINⅢ及ICC组织中呈高表达，二者之间有显著性差异（P〈0．05）。结论：VEGF在CINⅢ及ICC中呈高表达，是监测CIN及ICC的一个重要的指标，并有助于探讨CIN及ICC的发病机制。
Objective： To explore the expression of vascular endothelial growth factor （VEGF） in the chronic cervicitis, cervical intraepithelial neoplasia （CIN） and invasive carcinoma of cervix （ICC） , in order to improve the the pre -operation diagnosis of CIN and ICC. Methods： Immunohistochemical technique was employed to study the expression of VEGF in 40 cases with the chronic cervicitis, 30 cases with CIN Ⅰ-Ⅱ, 25 cases with CIN Ⅲ and 30 cases with ICC. All cases were employed by HE stain. Results： The expression of VEGF in the chronic cervicitis and CIN Ⅰ-Ⅱ was little and remarkably lower than that of CINⅢ and ICC （P 〈0. 05） . Conclusion： The high expression of VEGF in CIN Ⅲ and ICC is a important indicator to detect the CINⅢ and ICC, it is useful to study the mechanism and to improve the diagnosis of CIN and ICC by detecting the expression of HPV.
出处
《中国妇幼保健》
CAS
北大核心
2007年第32期4596-4598,共3页
Maternal and Child Health Care of China
