摘要
目的 观察生大黄对孕鼠早期妊娠子宫内膜微细结构的影响。方法 妊娠ICR小鼠 80例 ,共分 4组 ,其中 3组分别经灌胃注入大、中和小剂量 (分别为 0 15克、0 0 5克和 0 0 15克 )的生大黄制剂 ,连续 4天 ;1组为对照组 ,灌等量蒸馏水4天。动物处死石蜡包埋子宫切片HE染色。光镜下观察受孕后 5至 7天孕鼠的流产情况以及子宫内膜组织的微细结构的变化。结果 随剂量增大 ,生大黄组的孕鼠流产率明显升高 ,对子宫内膜的微细结构影响增大 ,小剂量生大黄对子宫内膜微细结构的影响不明显。结论 生大黄的下泻作用常常造成妊娠个体的流产 ,而对子宫内膜微细结构的损害可能是导致胚胎夭折的原因之一。
Objective To observe the strcture of endometrium in uterus of the experimental mice which were affected by Rheum Palmatum L. Methods Eighty cases Swiss Hauschka mice were divided four groups. Three groups pregnancy mice were injected separately large,middle and small dose of Rheum Palmatum L.,and the fourth group used as control.The number of abortions and the structure of uterus endometrium had been studied by microscopy. Result It was showed that the Large dose group increased rate of abortion,and the strcture of uterus endometrium became abnormal. Conclusion As Rheum Palmatum L.always gave rise to diarrhea,so that it can be the cause of abortions. Otherwise,the structural injury of uterus endometrium may lead to embryos abort.
出处
《解剖学研究》
CAS
2000年第1期30-31,共2页
Anatomy Research
关键词
大黄
妊娠
小鼠
子宫内膜
中药
药理
Rheum Palmatum L
Pregnancy
Mouse
Uterus
Endometrium
