摘要
目的探讨婴幼儿喘息与过敏原及免疫细胞亚群变化对预测哮喘发生的相关性.方法选择2011年01月-2012年01月住院治疗的有喘息症状的下呼吸道感染婴幼儿共113例,依据血过敏原检测结果分为过敏原阳性组51例和过敏原阴性组62例,对病史以及患者血T细胞、B细胞和NK细胞进行相关性分析.结果过敏原阳性组有过敏性疾病史、过敏性家族史及既往有喘息史的患儿比率都较过敏原阴性组高;过敏原阳性组CD4＋和CD16＋CD56＋百分率明显低于阴性组,CD8＋和CD19＋CD23＋百分率则高于阴性组.结论婴幼儿过敏原检测与免疫细胞亚群分析可预测喘息发展成哮喘的可能性.
Objective To discuss the possibility of allergen and immune cell subsets changes in predicting the occurrence of asthma in wheezy infants.Methods Totally 113 patients with asthmatic pneumonia were hospitalized from Jan 2011 to Jan 2012 were enrolled.Patients were grouped into positive group（n=51） and negative group（n=62） based on the results of allergen test.Two groups were collected the history and detected for T lymphocyte,B lymphocyte and natural killer cell in peripheral blood.Results In positive group,the percentage of patients who had allergic disease history,allergic family history and wheezing history were significantly greater compared to the negative group.The percentage of CD4＋ and CD16＋CD56＋were lower in the positive group than those in the negative group,the percentage of CD8＋ and CD19＋CD23＋ were higher than the negative group. Conclusion Infant allergen test and subsets of immune cells analysis can predict the possibility of wheezing turning into asthma.
出处
《中国血液流变学杂志》
CAS
2013年第1期126-128,171,共4页
Chinese Journal of Hemorheology
基金
苏州市社会发展科技计划项目（SS0702）
关键词
婴幼儿
喘息
过敏
免疫细胞亚群
infants
wheezing
allergy
immune cells subsets
