摘要
目的 探讨外周血CD2 3表达阳性B淋巴细胞 (CD2 3+/CD19+)在婴幼儿哮喘中的表达及对婴幼儿喘息预后的早期预测价值。方法 用流式细胞术测定 5 3例喘息性支气管炎 (喘息组 )、17例婴幼儿哮喘 (哮喘组 )、18例婴幼儿肺炎患儿 (肺炎组 )及 2 2例正常对照组儿童的外周血淋巴细胞CD2 3+/CD19+表达。并对 5 3例喘息性支气管炎做进一步随访。结果 (1) 5 3例喘息性支气管炎患儿在随访 3年后 ,最终发展为儿童哮喘的有2 0例 (喘息Ⅰ组 ) ,喘息终止 33例 (喘息Ⅱ组 )。 (2 )婴幼儿哮喘组CD2 3+/CD19+表达较婴幼儿肺炎组、对照组增高 ,差异有显著性 (P <0 0 1) ;婴幼儿肺炎组与对照组比较差异无显著性 (P >0 0 5 )。 (3)喘息Ⅰ组CD2 3+/CD19+表达较婴幼儿肺炎组和对照组升高 (P <0 0 1) ,与婴幼儿哮喘组比较差异无显著性 (P >0 0 5 ) ;喘息Ⅱ组CD2 3+/CD19+表达与肺炎组、对照组比较差异无显著性 (P >0 0 5 )。 (4)喘息Ⅰ组CD2 3+/CD19+表达与喘息Ⅱ组比较差异有显著性 (P <0 0 1)。结论 婴幼儿哮喘及最终发展为哮喘的喘息性支气管炎患儿喘息早期表达CD2 3+/CD19+增高 ,CD2 3+/CD19+对婴幼儿喘息预后早期预测可能有重要价值。
Objective To investigate whether CD23+/CD19+(CD23 positive expressions on B lymphocytes)expressions are increased in infants with asthma and its value in predicting the development of asthma in infants experiencing their early episodes of wheezing.Methods In a prospective trial,the CD23+/CD19+ expressions on peripheral blood lymphocytes from 53 infants with wheezy bronchitis,17 infants with asthma,20 infants with pneumonia and 22 healthy infants were analyzed by flow cytometry.At a three-year follow-up,53 children with wheezy bronchitis were re-evaluated for a diagnosis of asthma by the same criteria.Results The number of the infants with asthma(GroupⅠ) were 20 and 33 without asthma in GroupⅡ.The CD23+/CD19+expressions were increased in the infants with asthma and in GroupⅠas compared with infants with pneumonia and healthy infants ( P <0.01).The CD23+/CD19+ expressions in GroupⅡ were not different compared with the infants with pneumonia,healthy infants ( P >0.05).There were no difference between the infants with asthma and the GroupⅠ( P >0.05) and between the infants with pneumonia and the healthy subjects ( P >0.05).The CD23+/CD19+ expressions were higher in GroupⅠthan in GroupⅡ( P <0.01).Conclusion The CD23+/CD19+ expressions are increased in infants with asthma and may be useful for predicting the development of asthma in wheezing infants in early onset of wheezy during infancy.
出处
《中国实用儿科杂志》
CSCD
北大核心
2004年第1期16-18,共3页
Chinese Journal of Practical Pediatrics
