摘要
目的探讨血浆同型半胱氨酸(Hcy)和B型钠尿肽(BNP)联合检测在急性心肌梗死(AMI)中的应用。方法选取150例AMI患者及135名健康体检者(正常对照组)。AMI患者分别于入院后和进行药物溶栓或经皮冠状动脉介入(PCI)治疗前、后检测其血浆BNP和Hcy水平。对住院和随访期间发生心血管事件的51例患者和未发生心血管事件的99例患者分别检测血浆BNP和Hcy水平并进行比较。结果 AMI组血浆BNP[(594.38±167.58)pg/mL]和Hcy[(37.6±11.44)μmol/L]水平明显高于正常对照组[(56.32±28.79)pg/mL、(7.62±3.18)μmol/L](P<0.05)。AMI患者经药物溶栓或PCI治疗后血浆BNP[(256.94±118.55)pg/mL或(78.03±11.24)pg/mL]和Hcy[(16.47±7.24)μmol/L或(10.33±6.09)μmol/L]水平明显低于药物溶栓前[(618.06±224.46)pg/mL、(39.66±9.54)μmol/L]或PCI治疗前[(494.37±183.63)pg/mL、(35.53±8.12)μmol/L](P均<0.05)。发生心血管事件组血浆BNP[(609.15±287.37)pg/mL]和Hcy[(39.5±12.61)μmol/L]水平明显高于未发生心血管事件组[(326.85±134.24)pg/mL、(14.56±7.12)μmol/L](P<0.05)。结论血浆BNP和Hcy水平与AMI有一定的关系,可作为AMI的临床应用指标。
Objective To investigate the application of the combination determination of plasma homocysteine （Hey） and B-type natriuretie peptide （BNP） in acute myocardial infarction （AMI）. Methods A total of 150 patients with AMI and 135 healthy subjects were enrolled. The levels of plasma BNP and Hey were determined after admission and drug thrombolysis or percutaneous coronary intervention （PCI） in patients with AMI. The levels of plasma BNP and Hey were compared between 51 patients with cardiovascular events and 99 patients without cardiovascular events during hospitalization and follow-up. Results The levels of plasma BNP [ （594.38 ± 167.58 ） pg/mL ] and Hcy [ （37.6 ± 11.44） μmol/L ] in patients with AMI were higher than those in healthy controls [ （ 56.32 ± 28.79 ） pg/mL and （7.62 ± 3.18 ） μmol/L ] （ P 〈 0.05 ）. After admission and drug thrombolysis or PCI, the levels of plasma BNP [ （ 256.94 ± 118.55 ） pg/mL or （ 78.03 ± 11.24 ） pg/mL ] and Hey [ （ 16.47 ± 7.24 ）μmol/L or （ 10.33 ± 6.09 ） μmol/L ] in patients with AMI were lower than those before admission and drug thrombolysis or PCI[ （494.37 ± 183.63 ）pg/mL and （35.53 ± 8.12 ）μmol/L ] （ P 〈 0.05 ）. The levels of patients with cardiovascular events [ BNP （ 609.15 ± 287.37 ） pg/mL and Hey （ 39.5 ± 12.61 ）μ mol/L] were higher than those without cardiovascular events [ BNP（ 326.85 ± 134.24 ） pg/mL and Hcy（ 14.56± 7.12） μmol/mL] （ P 〈 0.05 ）. Conclusions The plasma BNP and Hey are related to AMI. Plasma BNP and Hcy may be as application parameters in AMI.
出处
《检验医学》
CAS
2013年第5期379-381,共3页
Laboratory Medicine
关键词
B型钠尿肽
同型半胱氨酸
急性心肌梗死
诊断
预后
B-type natriuretic peptide
Homocysteine
Acute myocardial infarction
Diagnosis
Prognosis
