摘要
目的:探讨增殖细胞核抗原(PCNA)、Ki-67及P53蛋白在前列腺癌中的表达及其临床病理意义。方法:采用免疫组化方法分别检测82例前列腺癌及20例前列腺增生(BPH)患者PCNA、Ki-67及P53蛋白表达,对其两者之间的差异进行分析比较。结果:PCNA、Ki-67及P53蛋白在前列腺癌中的表达率高于在前列腺增生(BPH)中的表达,差异有统计学意义(P<0.05),在低分化前列腺癌(G3)及有淋巴结转移者的表达率高于在高分化前列腺癌(G1)及无淋巴结转移者的表达,差异有统计学意义(P<0.05)。结论:PCNA、Ki-67及P53蛋白在前列腺癌中的表达率与病理分级及淋巴结转移有关,联合检测PCNA、Ki-67及P53蛋白对前列腺癌的早期诊断、临床预后具有一定意义。
Objective： To investigate the expression and clinicopathological significance of PCNA, Ki-67 and P53 protein in prostate cancer.Methods： To detect the expression of PCNA, Ki-67 and P53 protein in 82 cases of prostate cancer and 20 patients with benign prostatic hyperplasia by immunohistoehemistry, then to analyze and compare the difference between them.Results： The expression of PCNA, Ki-67 and P53 protein in prostate cancer was higher than which in benign prostatic hyperplasia, it was statistically significant difference（P〈0.05）, and it was higher in prostate cancer which was poorly differentiated（G3） or lymphatic metastasis than which in high differentiation（G1） or without lymphatic metastasis, it was statistically significant difference too（P〈0.05）.Conclusion： The expression of PCNA, Ki-67 and P53 protein in prostate cancer is related to the pathological grade and lymphatic metastasis, it has a certain significance to the early diagnosis and the clinical prognosis of prostate cancer by detected the expression of PCNA, Ki-67 and P53 protein jointly.
出处
《中外医学研究》
2013年第15期53-54,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
