摘要
目的探讨PCNA和ki-67在非小细胞肺癌中的表达及意义。方法收集临床手术切除的非小细胞肺癌组织蜡块128例及正常肺组织32例,应用免疫组化检测组织中PCNA和Ki-67的表达,结合临床病理资料和随访资料进行回顾性研究。结果发现非小细胞肺癌组织中PCNA的表达和Ki-67表达均明显高于正常肺组织(P<0.01)。PCNA表达增高与肿瘤病理分级、分期增加以及淋巴结转移之间有相关性(P<0.01),但与肿瘤组织学分型无相关性(P>0.05)。PCNA表达与Ki-67表达之间呈显著正相关(P<0.01)。结论 PCNA及Ki-67高表达是影响患者预后的主要因素,两者的异常表达与肺癌的发生、发展及转移关系密切,对判断肺癌恶性程度及预后有重要参考价值。
Objective To study the relationship between expression of Ki-67,PCNA and metastasis and prognosis in patients with non-small cell lung cancer.Methods The expression of Ki-67 and PCNA were examined with immunohistochemical technique in 128 specimens of NSCLC and 32 normal neighboring lung tissues.Results The expression of Ki-67 and PCNA in NSCLC tissues was significantly higher than that in benign pulmonary lesion.The results showed that the expression of Ki-67 and PCNA might be helpful for predicting prognosis of patients with NSCLC.Conclusion The expression of Ki-67 and PCNA in NSCLC tissues was significantly higher than that in normal lung tissues,and was closely related to the pathogenesis and progression of tumor.Examinations of the expression of Ki-67 and PCNA in lung cancer were helpful in predicting prognosis of lung cancer and guide the multi-therapy for the patients with NSCLC.
出处
《临床军医杂志》
CAS
2011年第2期261-263,共3页
Clinical Journal of Medical Officers
关键词
肺癌
PCNA
KI-67
免疫组化
non-small cell lung cancer
PCNA
Ki-67 antigen
immunohistochemistry
