摘要
通过生存曲线及多因素分析 ,探讨原发性胃肠道淋巴瘤的临床特征与预后的关系。方法 :选择我院自1990年至1996年的原发性胃肠淋巴瘤共92例 ,均经病理确诊 ,并进行了含ADM为主方案多程化疗和/或手术切除治疗 ,同时有良好的随访。结果 :Kaplan Meier生存分析结果 ,2年的累积生存率为67 0 % ,5年的预计累积生存率为54 3 % ,平均生存期为54 8月 (95 %可信区间47 4～60 1月 ) ,5年无病生存率为63 1 %。按照AnArbor分期进行生存分析 ,5年总生存率及无病生存率分别为 :Ⅰ期均为85 7 % ,Ⅱ期63 4 %和54 8 % ,Ⅲ期19 4 %和22 2 % ,Ⅳ期13 9 %和5 6 % ,Log rank分析生存曲线有显著差异 (P=0 0001)。5年预计总生存期及无病生存期在PS状态、LDH酶、B症状、大肿物组病理类型这几个临床指标中均有显著差异。多因素分析5年预计总生存期与分期、病理类型、PS状态及LDH酶水平有关 ,无病生存期与分期及PS状态有关。结论 :胃肠道淋巴瘤的临床特征与其预后密切相关 ,目前常用的手术联合化疗治疗早期的胃肠道淋巴瘤取得较好的疗效 ,但手术治疗是否是必须的 。
Objective:The goal of this work was to explore the relationship between the clinical outcome of primary gastrointestinal non Hodgkins lymphoma and the various clinical characteristics Methods: From 1990 to1996, 92 cases of primary gastrointestinal non Hodgkins lymphoma histologically proven were analyzed All those patients received chemotherapy with or without operation Results: The 2 year cumulative survival rate was 67 0%in the whole group, and the 5 year survival rate was 54 3%, the mean survival time was 54 8 months (95%confidence interval, 47 4～60 1 months) The 5 yeardisease free survival rates were 85 7%in stage Ⅰ, 63 4%in stage Ⅱ, 19 4%in stage Ⅲ, and 13 9%in stage Ⅳ, respectively, while the 5 year total survival rates were 85 7%, 54 8%, 22 2%, and 5 6%, respectively There were significant differences of the survival rate among the different stages of the disease by Log rank test And there were also differences of the other clinical characteristics, including PS, LDH, B symptom, bulky disease, and histological types Multivariate analysis showed that the 5 year survival time was associated with stage, histological type, PS and LDH, while the 5 year disease free survival time, was associated with stage and PS Conclusions: The prognosis of primary gastrointestinal non Hodgkins lymphoma was related with various clinical characteristics The commonly combined modality of radical resection and chemotherapy for early stage patients may obtain a good efficacy However,whether it is necessary to conduct radical resection in the early stage patients is not clear yet and need to be further clarified
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2000年第8期821-824,共4页
Chinese Journal of Cancer
