摘要
目的:探讨初治时伴结外侵犯的非霍奇金淋巴瘤(non-Hodgkins lymphoma,NHL)的临床病理特征及其与疗效的关系。方法:回顾性分析初治伴结外侵犯的NHL患者224例,分析其临床病理特征,采用χ2检验,比较不同临床特征与完全缓解率之间的关系。结果:224例伴结外侵犯的患者中B细胞NHL140例,主要为弥漫大B细胞淋巴瘤(77例);T细胞NHL84例,主要为外周T细胞淋巴瘤非特指型(53例)。伴结外侵犯的B细胞NHL,最常见的侵犯部位是咽淋巴环、胃肠道和浆膜腔;伴结外侵犯的T细胞NHL,最常见的侵犯部位是咽淋巴环和鼻腔副鼻窦。B细胞NHL完全缓解率为34.3%(48例),T细胞NHL完全缓解率为31.0%(26例)。Ⅲ～Ⅳ期、B症状、体能状况差、巨大包块者完全缓解率低;性别、LDH及是否放疗与完全缓解率无相关性,P>0.05;国际预后指数(IPI)不同的患者,其完全缓解率差异有统计学意义(B细胞性淋巴瘤P=0.023,T细胞性淋巴瘤P=0.014)。结论:伴结外侵犯的NHL最常见的病理类型是弥漫大B细胞淋巴瘤和外周T细胞淋巴瘤非特指型,其完全缓解率低,可以利用IPI指数预测其疗效与预后。
OBJECTIVE： To retrospectively analyze the clinicopathologic characteristics and treatment response of 224 cases of non-Hodgkin lymphoma （NHL） with extranodal involvement and explore the association between the clinical characteristics and prognosis. METHODS： A total of 224 cases of lymphoma with extranodal involvement treated in Guangxi cancer hospital were retrospectively analyzed, and the association between the clinical factors and the probability of attaining complete remission （CR） was evaluated by Chi-square test. RESULTS： Among 224 cases, 140 cases were B cell NHL, and the most common pathological type was diffuse large B cell lymphoma （77）, the most frequent extranodal involvement sites were waldeyer＇s ring, gastrointestinal tract and serous cavity; 84 cases were T cell NHL, and the most common pathological type was peripheral T cell lymphoma-unspecified （53）, the most frequent extranodal involvement sites were waldeyer＇s ring and nasal cavity. The CR rates were 34.3% （48） in B cell NHL and 31. 0%（26） in T cell NHL, and the factors associated with a lower probability of achieving CR were advanced disease （stage Ⅲ-Ⅳ ）, poor PS, bulky disease. LDH levels, gender and radiotherapy were not significantly associated with CR rate. The patients with different IPI significantly showed various CR rates （ P values were 0. 023 in B cell lymphoma and 0. 014 in T cell lymphoma, respectively）. CONCLUSIONS： The most common subgroups of NHL with extranodal involvement are diffuse large B cell lymphoma and peripheral T cell lymphomaunspecified, and there is a low CR rate in these cases. IPI is proved to be of highly significant prognostic value.
出处
《中华肿瘤防治杂志》
CAS
2007年第22期1721-1724,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
淋巴瘤
非霍奇金
结外侵犯
临床特征
预后
lymphorna, non-Hodgkin
extranodal involvement
clinical characteristics
prognosis
