摘要
目的调查咸宁市第一人民医院鲍氏不动杆菌的标本分布和耐药性,为临床合理用药提供参考依据。方法收集2009年1月-2011年12月医院感染鲍氏不动杆菌的临床资料,采用纸片扩散法测定菌株对抗菌药物的敏感性。结果鲍氏不动杆菌感染科室分布以ICU、神经外科、呼吸内科多见,分别占28.84%、23.28%、22.49%;标本主要来源于痰液,占70.63%;鲍氏不动杆菌的耐药率依次为氨曲南为79.37%、头孢西丁为69.31%、磺胺甲噁唑/甲氧苄啶为66.40%、哌拉西林为64.81%、头孢吡肟为64.02%、头孢噻肟为61.90%、左氧氟沙星为61.38%,而对亚胺培南为25.66%、头孢哌酮/舒巴坦为16.67%,耐药率相对较低。结论鲍氏不动杆菌引起的医院感染非常严重,应加强对鲍氏不动杆菌引起的医院感染耐药性监测,合理应用抗菌药物。
OBJECTIVE To investigate the distribution and the drug resistance of Acinetobacter baumannii isolated form the clinical specimens obtained from the Xianning First People＇s Hospital so as to provide basis for the reasonable use of antibiotics. METHODS The clinical data of the patients with A. baurnannii infections were collected from Jan 2009 to Dec 2012, the disk diffusion method was employed to perform the drug susceptibility testing. RESULTS The patients with A. baurnannii infections distributed mainly in ICU（28.84%）, neurosurgery department（23.28%）, and respiratory medicine department（22.49%）. The specimens were mainly obtained from the sputum, accounting for 70. 63%. The drug resistance rates of the A. baumannii to various antimicrobiai agents, from high to low, were as follows： aztreonam （79. 37%）, cefoxitin （69. 31%）, sulfamethoxazole/ trimethoprim（66： 40%）, piperacillin （ 64. 81%）, cefepime （ 64. 02%）, cefotaxime （ 61. 90%）, and levofloxacin （61.38%）. While the resistance rates to imipenem（25. 66%） and cefoperazone/sulbactam was（16. 67%） were relatively low. CONCLUSION The nosocomial infections caused by A. baumannii is very serious, thus, it is ： necessary to strengthen the monitoring of drug resistance of the A. baumannii strains causing nosoeomial infections and reasonably use antibiotics.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第10期2467-2469,共3页
Chinese Journal of Nosocomiology
关键词
鲍氏不动杆菌
医院感染
耐药性
Acinetobacter baumannii
Nosoeomial infection
Drug resistance
