摘要
目的了解鲍氏不动杆菌(ABA)流行株耐药基因携带状况和菌株的亲缘性,为医院流行病学溯源提供依据。方法对39株ABA采用PCR检测19种耐药基因(TEM、SHV、PER、VEB、GES、CARB、CTX-M-1群、OXA-23群、OXA-24群、IMP、VIM、DHA、aac(3)-Ⅰ、aac(3)-Ⅱ、aac(6′)-Ⅰ、aac(6′)-Ⅱ、ant(3″)-Ⅰ、ant(2″)-Ⅰ、qacE△1-sul1)。结果TEM阳性13株(33.3%)、OXA-23群阳性20株(51.3%)、aac(3)-Ⅰ阳性25株(64.1%)、aac(6′)-Ⅰ阳性25株(64.1%)、ant(3″)-Ⅰ阳性29株(74.4%)、qacE△1-sul1阳性32株(82.1%),其余基因均阴性;聚类分析提示存在克隆传播现象。结论ABA流行株β-内酰胺酶、氨基糖苷类修饰酶和消毒剂-磺胺耐药基因携带率高,存在克隆传播医院感染流行的危险。
OBJECTIVE To investigate the drug-resistant genes in Acinetobacter baumannii （ABA） isolated from Shaoxing and the relationship among them to supply evidences for tracing the source of epidemiology. METHODS Nineteen drug-resistant genes were detected by PCR in 39 strains of ABA. RESULTS TEM-gene was found positive in 13 strains of ABA（33.3%）, OXA-23 group-gene was in 20 strains（51.3%）, aae（3）- I gene was in 23 strains（64.1%）, aac（6＇）-Ⅰ gene was in 25 strains（64.1%）, ant（3＂）-Ⅰ gene was in 29 strains（74.4%） andqacE△1-sull gene was in 32 strains （81. 2%）. The others were not found in all 39 isolates detected. Clonial transmitted phenomenon was existed. CONCLUSIONS The carrier rate of TEM, OXA-23group, aae（3）-Ⅰ , aae （6＇）-Ⅰ, ant（3＂）-Ⅰ and qac△1-sull genes is high in ABA. ABA can induce clonial transmitted hospital infection.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第16期2082-2084,共3页
Chinese Journal of Nosocomiology
关键词
鲍氏不动杆菌
耐药基因
亲缘性
Acinetobacter baurnannii
Resistant genes
Relationship
