摘要
目的:观察乳果糖口服液干预产后排便困难的临床效果及安全性。方法:将2010年11月1日～2011年2月28日在重庆医科大学第一附属医院产科剖宫产分娩的292例产妇随机分为试验组142例和对照组150例,试验组口服乳果糖口服液治疗2周,停药后随访2周。对照组不给药,随访4周。观察两组产妇的大便性状、大便频率、排便时间及不良反应的改善情况。结果:用药2周后,试验组的大便频率、排便时间及大便性状改善的总有效率为95.8%(136/142),与对照组的88.7%(133/150)比较差异有统计学意义(P<0.05)。4周后两组总不良反应率比较差异无统计学意义(P>0.05)。结论:利动(乳果糖)干预产后排便困难的疗效满意,不良反应未见显著增加,安全性高,是预防产后排便困难的一种安全有效的药物。
Objective： To assess the efficacy and safety of lactulose in the intervention treatment of constipation for women after pregnancy. Methods ： A two - week, randomized, muhicenter study was carried out in 294 women during postpartum period. They were ran- domly divided into two groups. The patients in therapy group were given oral lactulose solution for 2 weeks. Patients in the control group were not given any treatment. All the subjects were asked to record the daily defecation frequencies, the stool consistency which was judged by the Bristol Stool Form Scale and the time spent for defecation. Also, the treatment emergent adverse events including abdominal pain, abdominal distention and borborygmus were observed and the delivery results were followed up by two weeks. Results： The changes in stool consistency, defecation frequency and defecation time in the lactulose group were much more better than those of the control group after two weeks admin- istration （ P 〈 0. 05 ） . There were no significantly differences in adverse events between the lactulose group and the control group （ P 〉 0. 05 ） . Conclusion： Laetulose is efficacious and safe for the intervention treatment of Postpartum women＇s constipation.
出处
《中国妇幼保健》
CAS
北大核心
2013年第14期2198-2201,共4页
Maternal and Child Health Care of China
关键词
乳果糖
排便困难
便秘
盆底功能
产后
Lactulose
Difficuh defecation
Constipation
Pelvic floor function
Postpartum
