摘要
目的观察乳果糖口服液治疗产后便秘的疗效与不良反应。方法选择产后发生单纯便秘、无其他病理因素的患者120例,采用随机数字表分为治疗组61例和对照组59例。治疗组给予乳果糖口服液15 m L,bid,po;对照组给予小麦纤维素颗粒3.5 g,bid,po,症状改善后药物均改为每天1次,疗程均为2周。观察患者治疗前、治疗中及治疗后1周疗效及复发情况。结果治疗组和对照组的周排便次数在治疗第1周时分别为(3.83±1.61),(3.09±1.53)次(P<0.05),治疗第2周时分别为(6.22±1.96),(5.15±1.71)次(P<0.01),治疗结束后1周时分别为(6.43±1.87),(5.29±1.64)次(P<0.01);对药物的接受程度分别为100.00%,76.27%(P<0.01)。治疗后60 d,治疗组和对照组总复发率分别为4.92%,10.17%(P>0.05)。两组均无明显不良反应。结论乳果糖口服液治疗产后便秘疗效确切,复发率低,无明显不良反应,患者易于接受,值得临床推广使用。
Objective To study the effect and adverse reaction of lactulose oral solution on the treatment of postpartum constipation. Methods A total of 120 patients with postpartum constipation were randomly divided into treatment group （ n = 61） and control group （ n = 59 ） . The treatment group received 15 mL lactulose oral solution,twice a day. The control group received wheat cellulose particles 3.5 g,twice a day. After the improvement of symptoms,the patient＇s medication frequency was changed to 1 time a day,the course of treatment was 2 weeks long. The curative effect（including before treatment,period during the treatment,and the first week after finish the whole treatment） and the recurrence of constipation after treatment were observed.Results The frequency of defecation per week in the treatment group was（3.83±1.61）times ,that in the control group was （3.09±1.53）times at the first week after treatment（P〈0.05）,those were（6.22±1.96）and（5.15±1.71）times respectively in the second week（P〈0.01）,and （6.43±1.87）, （5.29±1.64）times respectively at the first week after treatment（P〈0.05）.The total recurrence rate in the two groups were 4.92% and 10.17% respectively（ P 〉0 .05 ） after follow-up to 60 d. The degree of drug
acceptance in two groups was 100.00% and 76.27% respectively（P 〈0.01）.There was no obvious adverse reaction in both two groups. Conclusion The effect of lactulose oral solution on the treatment of postpartum constipation is definite and with low recurrence rate. Lactulose oral solution has a good taste, easily to be taken and to be accepted, it is worthy of clinical application.
出处
《医药导报》
CAS
2017年第9期996-1000,共5页
Herald of Medicine
关键词
乳果糖口服液
便秘
产后
复发
Lactulose oral solution
Constipation,postpartum period
Recrudesce
