摘要
自从1912年Bass等首次报道体外培养恶性疟原虫(Plasmodium falciparum,Pf)以来,学者们对体外培养恶性疟原虫的技术和营养环境优化研究从未停止过,直到1976年Trager和Haynes先后宣布疟原虫连续体外培养成功。本文对近年来疟原虫红外期体外培养技术及其改良方法,以及利用体外培养恶性疟原虫进行红外期疟原虫生物学特性超微结构、生理生化、药理学研究的进展作简要概述。
Since Bass first reported the in vitro culture of falciparum malaria （Plasmodium falciparum） in 1912, re- searchers never stopped to study techniques for its culture in vitro and its optimal nutritional environment until 1976, when Trager and Haynes announced the successful continuous in vitro culture of P. falciparum. The current paper sum- marizes advances in techniques for the in vitro culture of the exoerythrocytic stage o{ P. falciparum, improvements in those techniques, and the use of in vitro culture of P. falciparum in studies of its biological
出处
《中国病原生物学杂志》
CSCD
北大核心
2013年第4期375-378,共4页
Journal of Pathogen Biology
基金
云南省全球基金疟疾项目(No 201201)
关键词
疟原虫
恶性
体外培养
综述
Plasmodium falciparum parasites
in vitro culture
review
