摘要
目的:观察舒血宁注射液与单硝酸异山梨酯注射液联合治疗冠心病心绞痛的临床疗效和药物安全性。方法:采用随机数字表法将93例冠心病心绞痛确诊患者分为2组,对照组给予静脉滴注单硝酸异山梨酯注射液,观察组给予静脉滴注舒血宁注射液联合单硝酸异山梨酯注射液,均治疗1周为一疗程,三个疗程后对比临床疗效和药物安全性。结果:观察组总有效率93.62%明显高于对照组76.09%,差异具有统计学意义(χ2=4.2999,P<0.05);观察组不良反应发生率4.27%明显低于对照组19.57%,差异具有统计学意义(χ2=3.8600,P<0.05)。结论:舒血宁注射液联合单硝酸异山梨酯注射液通过多机制、多靶点协同改善冠心病心绞痛患者心肌缺血缺氧状态疗效显著,安全可靠。
Objective：To observe the effect of Shuxuening injection and Isosorbide Mononitrate Injection in treatment of angina pectoris of coronary heart disease clinical efficacy and drug safety.Methods： using a random number table 93 cases of angina pectoris of coronary heart disease diagnosed patients were divided into 2 groups,the control group was given an intravenous infusion of Isosorbide Mononitrate Injection,the observation group was given an intravenous infusion of Shuxuening injection combined with Isosorbide Mononitrate Injection,were treated for 1 weeks,after three courses of comparative clinical efficacy and drug safety.Results： the total effective rate in the observation group 93.62% was significantly higher than that in control group 76.09%,the difference was statistically significant（χ2 =4.2999,P 0.05）;the incidence rate of adverse reaction of 4.27% observation group was significantly lower than that in control group 19.57%,the difference was statistically significant（χ2 =3.8600,P 0.05）.Conclusion： the effect of Shuxuening injection combined with Isosorbide Mononitrate Injection through multiple mechanisms,multiple target synergistically improve angina pectoris of coronary heart disease with myocardial ischemia and hypoxia of obvious curative effect,safety and reliability.
出处
《中国医药导刊》
2013年第3期483-484,共2页
Chinese Journal of Medicinal Guide
关键词
舒血宁注射液
单硝酸异山梨酯注射液
冠心病心绞痛
药物安全性
Shuxuening injection
Isosorbide Mononitrate Injection
Coronary heart disease and angina pectoris
Drug safety
