摘要
目的评估职业性急性1,2-二氯乙烷中毒患者应用糖皮质激素所致骨量减少与血脂、血钙的相关性。方法选取某院2009年～2012年期间应用糖皮质激素治疗的职业性急性1,2-二氯乙烷中毒患者38例,采用双能X线骨密度仪测定相关部位的骨密度,记录低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(CHOL)、甘油三酯(TRIG)、血清总钙(TCa)等临床资料,资料录入和统计采用SPSS统计软件包。结果 LDL-C、CHOL、TCa对骨量存在影响(P<0.05),而HDL-C、TRIG则对骨量无影响(P>0.05)。结论职业性急性1,2-二氯乙烷中毒患者应用糖皮质激素,可引起骨量减少或骨质疏松,严格控制血脂可能有助于减少骨量丢失。
Objective To evaluate the relationship among serum lipid, calcium, and osteopenia in patients after the treatment of occupational acute 1,2-dichloroethane poisoning with glueocorticoids. Methods A total of 38 patients, who had occupational acute 1,2-dichloroethanc poisoning and received glucocorticoid treatment in our hospital from 2009 to 2012, were enrolled. Bone mineral density was detected using dual- energy X-ray absorptiometry. Clinical parameters including low density lipoprotein eholesterin （LDL-C）, high density lipoprotein cholesterol （HDL-C）, total cholesterol （CHOL）, triglyceride （TRIG）, and serum total calcium （TCa） were recorded. A SPSS 16.0 software was used for statistical analysis. Results The concentrations of LDL-C, CHOL, and TCa were correlated with osteopenia （P 〈 0. 05） , whereas the concentrations of both HDL-C and TRIG showed no correlation with ostcopenia （P 〉 0.05）. Conclusion The usage of glucocorticoids in patients with occupational acute 1,2-dichloroethane poisoning can cause osteopenia or osteoporosis. Strict control of serum lipid level may help preventing the loss of bone mass.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2013年第4期349-351,406,共4页
Chinese Journal of Osteoporosis
关键词
1
2-二氯乙烷中毒
骨量
血脂
血钙
1,2-dichloroethane poisoning
Bone mass
Blood fat
Blood calcium
