摘要
目的:探讨癫痫患儿卡马西平血药浓度与临床疗效、给药剂量、性别、年龄和体质量的相关性。方法:回顾性查阅我院临床药学室158例/次癫痫患儿卡马西平血药浓度监测记录,将浓度值、性别、年龄等资料录入数据库,利用SPSS13.0软件进行分析处理。结果:癫痫患儿卡马西平血药浓度值与性别不存在明显的相关性,但与临床疗效、给药剂量、年龄和体质量密切相关。结论:卡马西平在患儿体内的代谢差异与年龄和体质量相关,应根据每位患儿自身的具体情况并结合血药浓度监测结果来制订个体化给药方案。
OBJECTIVE：To approach the correlations of carbamazepine concentration in serum with clinical therapeutic effect,dosage,sex,age and body weight in epileptic children.METHODS：158 monitoring records for serum concentration of carbamazepine in children with epilepsy in our clinical pharmacy department were consulted retrospectively.Data such as serum concentration,sex and age were recorded into data base and were analyzed using SPSS 13.0 software.RESULTS：No significant correlation was noted between serum concentration of carbamazepine in epileptic children and sex.However,serum concentration of carbamazepine was closely correlated with clinical therapeutic effect,dosage,age and body weight.CONCLUSION：The individual difference in the metabolic processes of carbamazepine was concerned with age and body weight,so it＇s necessary to make individualized regime according to child＇s specific condition and monitoring results.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第30期2846-2848,共3页
China Pharmacy
关键词
癫痫
儿童
卡马西平
治疗药物监测
相关性
Epilepsy
Children
Carbamazepine
Therapeutic drug monitoring
Correlation
