摘要
目的 血管紧张素Ⅱ的Ⅰ型受体 (Ⅰ型ATR)基因A116 6C多态性与 2型糖尿病及合并冠心病的关系。方法 用聚合酶链反应 限制性片段长度多态性 (PCR RFLP)分析法探查Ⅰ型ATR基因A116 6C多态性在正常对照组、单纯 2型糖尿病组、2型糖尿病合并冠心病组中的基因频率分布。结果 2型糖尿病合并冠心病组Ⅰ型ATR的C等位基因频率明显高于正常对照组 (χ2 =6 .0 2 ,P <0 .0 5 )和单纯 2型糖尿病组 (χ2 =5 .71,P <0 .0 5 ) ,且与甘油三酯和脂蛋白 (a)相关 (分别r=0 .143,P <0 .0 5 ;r =0 .2 15 ,P <0 .0 1)。结论 携带C等位基因的 2型糖尿病患者比携带A等位基因更易罹患冠心病 ,并在一定程度上与血脂代谢相关联。
Objective To determine whether the angiotensin Ⅱ type Ⅰ receptor (type Ⅰ ATR) gene A1166C polymorphism is associated with coronary heart disease (CHD) in type 2 diabetic patients. Methods To investigate the allele frequency and the genotype distribution of the type Ⅰ ATR gene A1166C polymorphism in the group of normal control, simple diabetes, diabetic CHD by means of polymerase chain reaction restriction fragment length polymorphism (PCR RFLP). Results The group of diabetic CHD had a higher frequency of C allele of the type Ⅰ ATR gene A1166C polymorphism than those of normal control (χ 2=6.02, P<0.05) and diabetes (χ 2=5.71, P<0.05), and the C allele is also correlated with higher triglycerideandlipoprotein(a) (r=0.143, P<0.05; r=0.215, P<0.01 respectively). Conclusion The patients of diabetes mellitus with type Ⅰ ATR C allele were more susceptible to coronary heart disease than the patients of diabetes mellitus with A allele, which is associated, at least to some extent, with lipid metabolism.
出处
《中华内分泌代谢杂志》
CSCD
北大核心
2000年第4期216-219,共4页
Chinese Journal of Endocrinology and Metabolism
关键词
糖尿病
冠心病
Ⅰ型ATR
基因多态性
AngⅡ
Diabetes mellitus
non insulin dependent
Coronary disease
Receptors
angiotensin
Polymorphism
restriction fragment length
