摘要
介绍了国内外大孔吸附树脂分离纯化药材和方剂中皂苷类成分的研究现状,总结了大孔树脂精制皂苷类成分的主要影响要素和数学建模方法,归纳出适合皂苷分离的大孔树脂特点。大孔树脂吸附皂苷类成分具有分离效率高,产品纯度高等特点,通过加强吸附和解吸等过程机制的研究,优化工艺参数,并开发色谱工艺控制策略可以进一步提高树脂精制效率,稳定皂苷产品质量。
This article was aimed to introduce researches on saponin purification with macroporous resin packed column chromatography both at home and abroad. Main influencing factors and mathematical modeling of chromatography process were discussed. Characteristics of macroporous resins which are recommended for saponin purification were summarized. Saponin purification with macroporous resin packed column chromatography is efficient in the obtaining of high purity saponin. Understanding of the mechanism of chromatography process, optimization of process parameters, and developing new chromatography process control strategy can be helpful to enhance separation efficiency and obtain saponins with stable quality.
出处
《世界科学技术-中医药现代化》
北大核心
2013年第2期329-334,共6页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
浙江省科技厅公益技术研究社会发展项目(2011C23095):大孔树脂吸附分离过程在线分析技术研究
负责人:龚行楚
高等学校博士学科点专项科研基金(20110101120149):基于中药体系特点的树脂吸附过程在线分析技术研究
负责人:龚行楚
关键词
大孔树脂
吸附
皂苷
Macroporous resin, adsorption, saponin
