摘要
目的 :探讨非小细胞肺癌 (NSCLC)DNA含量和细胞凋亡的关系。方法 :应用流式细胞技术检测 35例NSCLC和 5例正常肺组织的DNA含量、凋亡率 ,计算DNA指数、增殖指数。结果 :NSCLC的DNA异倍体出现率为71.43% ,DNA指数、增殖指数显著高于正常肺组织 ,异倍体尤其明显 ;NSCLC的凋亡率显著低于正常肺组织 ,并与DNA指数负相关 (r=- 0 .35 80 ,P =0 .0 0 3 5 )。结论 :DNA含量增加、增殖活性增强和凋亡减少在NSCLC具有普遍意义 ,异倍体尤其明显。
Objective:To study the correlation between DNA content and apoptosis in non small cell lung cancer (NSCLC).Method: DNA content and apoptotic ratio in 35 cases of NSCLC and 5 cases of normal lung tissues were studied by flow cytometry, DNA index and proliferation index were calculated.Results:The percent of DNA aneuploidy was 71.43% in cases with NSCLC, DNA index and proliferation index tended to be higher than that in normal lung tissue, especially the aneuploidy; the apoptotic ratio was lower in NSCLC than that in normal lung tissue, and showed negative correlation with DNA index( r =-0.3580, P =0.0035).Conclusions:The inerease of DNA content, proliferation ability improvement and decrease of apoptosis were common in NSCLC, especially in aneuploidy.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2000年第8期578-581,共4页
Chinese Journal of Clinical Oncology
基金
天津市高等学校科技发展基金资助!(编号97520)
