摘要
目的综述MSCs修复烧伤创面的研究进展。方法广泛查阅MSCs参与修复烧伤创面及其相关机制方面的文献,并进行分析总结。结果 MSCs具有自我更新、快速增殖、分化及旁分泌功能,通过分化为各种皮肤创面细胞及调节创面微环境,促进烧伤创面修复。结论 MSCs在烧伤领域具有广阔应用前景,但烧伤创面的恶劣微环境也对细胞生存及转归提出了挑战。
Objective To review the research progress of mesenchymal stem cells （MSCs） in burn wound repair. Methods The recent literature about MSCs involved in burn wound repair and mechanism was extensively reviewed and analyzed. Results MSCs have the capacity of self-renew, rapid proliferation, differentiation and paracrine, and promote burn wound repair through differentiating into a series of skin wound cells and regulating wound microenvironment. Conclusion MSCs have great potentials in the burn field. However, the cell survival and outcome are also facing challenges from poor microenvironment of the burn wound.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2013年第5期571-574,共4页
Chinese Journal of Reparative and Reconstructive Surgery
基金
国家科技支撑计划资助项目(2009BAI87B03)
解放军总医院第一附属医院院管课题资助项目(QN201207)~~
关键词
MSCS
增殖
分化
旁分泌
烧伤
创面修复
Mesenchymal stem cells Proliferation Differentiation Paracrine Burn Wound repair
