摘要
目的:探讨血必净注射液对严重烧伤患者脏器功能的影响。方法:将同期严重程度相当的中度以上烧伤住院患者40例随机分为治疗组(n=20)和对照组(n=20)。对照组按烧伤常规治疗;治疗组在对照组治疗的基础上加用血必净注射液,特重度烧伤每次100ml,中、重度烧伤每次50ml静脉滴注,每日3次,连续使用7d。检测两组患者治疗前后的肝功能、肾功能、凝血指标、心肌酶、动脉血气分析、血清白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)等。结果:治疗组和对照组中度烧伤患者各6例,各项检测指标比较差异均无显著性(P均>0.05)。两组重度以上烧伤患者各14例,血必净注射液治疗后,肝功能、肾功能、凝血指标、心肌酶、动脉血气分析、IL-6和TNF-α与治疗前比较均明显改善(P均<0.05);与对照组比较,治疗组患者的各项脏器功能指标及IL-6和TNF-α均明显改善(P均<0.05)。结论:血必净注射液能显著降低严重烧伤患者炎症介质的释放,有效保护患者的脏器功能。
Objective： To investigate the protective effects of Xuebijing injection （血必净注射液） on organ function in severe burn patients. Methods： Forty cases with comparative severity in burn injury were randomly divided into Xuebijing injection treatment group （n = 20） and control group （n = 20）. Patients in both groups received routine burn therapy, while those in treatment group additionally received intravenous dripping of Xuebijing injection 3 times a day for 7 days. The dosage of Xuebijing injection was 100 ml in extremely severe burns and 50 ml in moderate and severe burns. The clinical findings were assessed and variables indicating functions of internal organs, including liver, kidney, myocardial enzymes, coagulation indexes and arterial blood gas analysis, as well as serum levels of interleukin - 6 （IL - 6） and tumor necrosis factor-6 （TNF-α） were detected before and after treatment in two groups. Results： In the comparison between the treatment group and the control group, there were no significant differences between variables indicating functions of patients with moderate burns （each group, n= 6, all P〉0.05）. In patients with severe and extremely severe burns （each group, n=14）, functions of liver and kidney, coagulation indexes, myocardial enzymes and arterial blood gas analysis, as well as serum levels of IL - 6 and TNF-α were improved significantly after Xuebijing injection treatment （all P^0. 05）. Compared with the control group, various organ functions and serum levels of IL - 6 and TNF-α of patients in treatment group were more obviously improved （all P〈0. 05 ）. Conclusion： Xuebijing injection could markedly lower serum levels of TNF-α and IL - 6, and obviously protect functions of multiple organs in patients with severe burn injury.
出处
《中国中西医结合急救杂志》
CAS
2007年第1期14-16,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
