摘要
目的探讨5-氨基酮戊酸光动力疗法（ALA。PDT）治疗女性宫颈尖锐湿疣（CA）的临床疗效。方法选取2011年3月-2012年9月广东省汕头市中心医院皮肤性病科门诊收治的65例宫颈CA患者，按数字随机法分为治疗组（35例）和对照组（30例）。治疗组采用ALA-PDT进行治疗，1周治疗1次，治疗1～4次后判断临床疗效；对照组采用电灼术进行治疗。两组随访时间均为3个月。结果治疗组中，4例患者经1次ALA-PDT治疗、6例经2次治疗、16例经3次治疗、8例经4次治疗病情获得完全缓解，完全缓解率为97．1％（34／35），复发率5．9％（2／34）。对照组中，26例患者一次性去除疣体，4例分批治疗，完全缓解率100％（30／30），复发率26．7％（8／30）。经统计学处理，两组间完全缓解率的差异无统计学意义（P〉0．05），复发率对照组明显高于治疗组（70=6．478，P〈0．05）。结论ALA-PDT治疗宫颈CA具有疗效好、复发率低、操作方便、耐受性好等优势，是一种值得临床推广的新方法。
Objective To investigate the clinical efficacy of 5-aminolevaflinic acid photodynamic therapy （ALA- PDT） on women with cervical condyloma acuminatum （CA）. Methods A total of 65 patients with cervical CA in the dermatology of Shantou Central Hospital from March 2011 to September 2012 were divided into treatment group （35 cases） and control group （30 cases） according random number method. The treatment group received ALA-PDT therapy once a week, and clinical efficacy was determined after treatment for 1 - 4 times. The control group carried out fulguration treat- ment. Two groups were followed up for 3 months. Results In treatment group, 4 cases after 1 treatment, 6 patients after 2 treatments, 16 cases after 3 treatments and 8 cases after 4 treatments achieved complete remission, the complete remis- sion rate was 97.1% （34/35）, recurrence rate was 5.9% （2/34）. In control group, 26 patients after 1 treatment, 4 cases after several treatments achieved complete remission, the complete remission rate was 100% （30/30）, the recur- rence rate was 26.7 % （8/30）. The difference of complete remission rates between two groups was not statistically signifi- cant （ P 〉 0.05）, but the recurrence rate of the control group was significantly higher than the treatment group （ Z2 = 6.478, P〈0.05）. Conclusions ALA-PDT therapy on cervical CA has good efficacy and low recurrence rate. It is easy to operate and well tolerated as a new clinical method.
出处
《国际流行病学传染病学杂志》
CAS
2013年第2期113-115,共3页
International Journal of Epidemiology and Infectious Disease
基金
汕头市医疗重点科技计划（2012113）
关键词
尖锐湿疣
5-氨基酮戊酸
光动力疗法
子宫颈
Condylomata acuminata
5-aminolevulinie acid
Photodynamic therapy
Cervix
