摘要
目的观察5氨基酮戊酸(5aminolevulinicacid,ALA)光动力疗法(photodynamictherapy,PDT)治疗鲍温样丘疹病的临床疗效。方法治疗组38例采用ALAPDT治疗,每周治疗1次,共治疗4次;对照组15例予以二氧化碳激光治疗。结果治疗组痊愈12例,显效12例,有效率为61.2%,复发2例,复发率16.7%,无明显疼痛、创面等副作用;对照组痊愈9例,显效3例,有效率为80.0%,复发5例,复发率55.5%,15例均有术后明显创面疼痛,8例合并创面感染,9例出现表浅瘢痕。两组之间有效率和复发率无显著性差异(P>0.05)。结论ALAPDT是治疗鲍温样丘疹病的一种安全、有效、无明显痛苦和不良反应的新疗法。
Objective To investigate the effect of photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) on Bowenoid papulosis. Methods Patients with Bowenoid papulosis (n=38) were given topical ALA followed by PDT.Fifteen cases of Bowenoid papulosis as controlled were treated using CO_2 laser.Results The effective rate was 61.2% after ALA-PDT and 80% after CO_2 laser treatment. And the recurrence rate of ALA-PDT and CO_2 laser were 16.7% and 55.5%,respectively. However,the difference of effective rate and recurrence rate between two groups did not reach statistical significance.Conclusion Results suggest that topical ALA-PDT is a simple,effective,no side effection treatment for Bowenoid papulosis.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2005年第4期209-210,共2页
The Chinese Journal of Dermatovenereology
基金
上海市卫生局科技发展基金课题(1427)
关键词
5-氨基酮戊酸
光动力
鲍温样丘疹病
5-aminolevulinic acid (ALA)
Photodynamic therapy (PDT)
Bowenoid papulosis
